Biotin-decorated anti-cancer nucleotide theranostic conjugate of human serum albumin: Where the seed meets the soil?

Tatyana V. Popova, Hamda Khan, Alexey S. Chubarov, Vladimir A. Lisitskiy, Natalya M. Antonova, Andrey E. Akulov, Oleg B. Shevelev, Evgenii L. Zavjalov, Vladimir N. Silnikov, Saheem Ahmad, Tatyana S. Godovikova

Результат исследования: Научные публикации в периодических изданияхстатья

2 Цитирования (Scopus)

Аннотация

Human serum albumin is playing an increasing role as a drug carrier in clinical settings. Biotin molecules are often used as suitable tags in targeted anti-tumor drug delivery systems. We report on the synthesis and properties of a new multimodal theranostic conjugate based on an anti-cancer fluorinated nucleotide conjugated with a biotinylated dual-labeled albumin. Interestingly, in vitro and in vivo study revealed stronger anti-tumor activity of the non-tagged theranostic conjugate than that of the biotin-tagged conjugate, which can be explained by decreased binding of the biotin-tagged conjugate to cellular receptors. Our study sheds light on the importance of site-specific albumin modification for the design of albumin-based drugs with desirable pharmaceutical properties.

Язык оригиналаанглийский
Страницы (с-по)260-264
Число страниц5
ЖурналBioorganic and Medicinal Chemistry Letters
Том28
Номер выпуска3
DOI
СостояниеОпубликовано - 1 фев 2018

Fingerprint Подробные сведения о темах исследования «Biotin-decorated anti-cancer nucleotide theranostic conjugate of human serum albumin: Where the seed meets the soil?». Вместе они формируют уникальный семантический отпечаток (fingerprint).

  • Цитировать