Bioactive mixed-ligand zinc(II) complexes with 1H-tetrazole-5-acetic acid and oligopyridine derivatives

Ekaterina A. Ermakova, Julia A. Golubeva, Ksenia S. Smirnova, Lyubov S. Klyushova, Ilia V. Eltsov, Alexander A. Zubenko, Leonid N. Fetisov, Alexandra E. Svyatogorova, Elizaveta V. Lider

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование


1H-tetrazole-5-acetic acid is bifunctional ligand that was employed for the synthesis of zinc(II) complexes in the presence of secondary ligands such as oligopyridines (dmphen – 4,7-dimethyl-1,10-phenanthroline, phendione – 1,10-phenanthroline-5,6-dione, phen – 1,10-phenanthroline, dmbipy – 2,2′-bi-4-picoline, bipy – 2,2′-bipyridine). Five new mixed-ligand zinc(II) complexes [Zn(dmphen)L]·H2O (1), [Zn(phendione)(H2O)L]·2H2O (2), [Zn(phen)L]·0,5H2O (3), {[Zn(dmbipy)L]·H2O}n (4) and [Zn(bipy)L]·H2O (5) have been synthesized and characterized by elemental analysis, IR spectroscopy and powder X-ray diffraction. All complexes have shown to possess thermal stability up to 250°C by thermogravimetric analysis, except for complexes 2 and 5, which have been stable up to 200° C. Crystal structures of polymeric complexes {[Zn(dmphen)(H2O)2L]·2H2O}n (1a) and 4 have been determined by single-crystal X-ray diffraction analysis. The effect of the compounds on viability of HepG-2, MCF–7 and MRC-5 cell lines has been investigated. Complex 2 was found to be the most cytotoxic with IC50 values of 6.4 ± 0.9 µM for HepG-2 cells and 2.6 ± 1.1 µM for MCF-7 cells. The antimicrobial activity of the complexes and ligands has been investigated against E. coli, S. aureus, P. italicum and C. steinii.

Язык оригиналаанглийский
Номер статьи116213
СостояниеОпубликовано - 15 янв. 2023

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