Automated Volumetric Analysis of Postoperative Magnetic Resonance Imaging Predicts Survival in Patients with Glioblastoma

Alexey L. Krivoshapkin, Gleb S. Sergeev, Alekey S. Gaytan, Leonid E. Kalneus, Vladislav P. Kurbatov, Orkhan A. Abdullaev, Nidal Salim, Dmitry V. Bulanov, Alexander E. Simonovich

Результат исследования: Научные публикации в периодических изданияхстатья

Аннотация

Background: Glioblastomas (GBMs) are primary brain tumors that are very difficult to treat. Magnetic resonance imaging (MRI) is the reference tool for diagnosis, postoperative control, and follow-up of GBM. The MRI tumor contrast enhancement part serves as a target for surgery. However, there are controversial data about the influence of pre- and postoperative tumor volumetric MRI parameters on overall survival (OS). Methods: Data of 57 patients with GBM were analyzed retrospectively. All patients had maximum safe resection and standard adjuvant treatment. All patients underwent 1.5-T MRI with contrast in the first 24 hours postoperatively. The data of pre- and postoperative volumetric parameters were analyzed using the original software. Results: Correlation analysis between the postoperative volume of the tumor contrast enhancement part and the patient's OS revealed a significant level (on the Chaddock scale) of inverse correlation. Residual tumor volume associated with OS of >6 months was determined as <2.5 cm3. The mortality risk in the first 6 months after tumor resection is 3.4 times higher when the tumor remnant is >2.5 cm3 (risk ratio, 3.4; P = 0.0002). Conclusions: The volume of MRI contrast-enhancing GBM remnants after surgery, automatically measured by the software, was a significant predictor for early postoperative progression and death.

Язык оригиналаанглийский
Страницы (с-по)e1510-e1517
Число страниц8
ЖурналWorld Neurosurgery
Том126
DOI
СостояниеОпубликовано - 1 июн 2019

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