Associations between the levels of estradiol-, progesterone-, and testosterone-sensitive mirnas and main clinicopathologic features of breast cancer

Tatiana Kalinina, Vladislav Kononchuk, Efim Alekseenok, Grigory Abdullin, Sergey Sidorov, Vladimir Ovchinnikov, Lyudmila Gulyaeva

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

Despite the existing advances in the diagnosis and treatment of breast cancer (BC), the search for markers associated with the clinicopathological features of BC is still in demand. MiRNAs (miRs) have potential as markers, since a change in the miRNA expression profile accompanies the initiation and progression of malignant diseases. The receptors for estrogen, androgen, and progesterone (ER, AR, and PR) play an important role in breast carcinogenesis. Therefore, to search for miRNAs that may function as markers in BC, using bioinformatic analysis and the literature data, we selected 13 miRNAs whose promoter regions contain binding sites for ER or AR, or putative binding sites for ER, AR, and PR. We quantified their expression in MCF-7 cells treated with estradiol, progesterone, or testosterone. The levels of miRNAs sensitive to one or more of these hormones were quantified in BC samples (n = 196). We discovered that high expression levels of miR-190b in breast tumor tissue indicate a positive ER status, and miR-423 and miR-200b levels differ between patients with and without HER2 amplification. The miR-193b,-423,-190a,-324, and-200b levels were associated with tumor size or lymph node status in BC patients, but the presence of these associations depended on the status and expression level of ER, PR, HER2, and Ki-67. We also found that miR-21 expression depends on HER2 expression in ER-and/or PR-positive BC. The levels of miRNA were significantly different between HER2 0 and HER2 1+ tumors (p = 0.027), and between HER2 0 and HER2 2+, 3+ tumors (p = 0.005).

Язык оригиналаанглийский
Номер статьи4
ЖурналJournal of Personalized Medicine
Том12
Номер выпуска1
DOI
СостояниеОпубликовано - янв. 2022

Предметные области OECD FOS+WOS

  • 3.02 КЛИНИЧЕСКАЯ МЕДИЦИНА
  • 3 МЕДИЦИНСКИЕ НАУКИ И ЗДРАВООХРАНЕНИЕ

Fingerprint

Подробные сведения о темах исследования «Associations between the levels of estradiol-, progesterone-, and testosterone-sensitive mirnas and main clinicopathologic features of breast cancer». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать