Association of Polymorphism in SCN5A, GJA5, and KCNN3 Gene with Sudden Cardiac Death

A. A. Ivanova, V. N. Maksimov, D. E. Ivanoshchuk, P. S. Orlov, V. P. Novoselov, S. V. Savchenko, M. I. Voevoda

    Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

    5 Цитирования (Scopus)

    Аннотация

    We studied association of single-nucleotide SCN5A (rs1805124), GJA5 (rs35594137), and KCNN3 (rs13376333) polymorphisms and sudden cardiac death. Humans died suddenly from cardiac causes (N=379) and unrelated sex- and age-matched control subjects were genotyped. No significant intergroup differences were found in the frequency of rs1805124 and rs13376333 genotypes and alleles. In women under 50 years, enhanced risk of sudden cardiac death was associated with rs35594137 GG genotype (OR=3.6; 95%CI=1.2-10.4; p=0.022), while in older women it was associated with rs35594137 AA genotype (OR=3.0; 95%CI=2.3-3.9; p=0.041). In women under 50 years, GA rs35594137 genotype was associated with a protective effect against sudden cardiac death (OR=0.3; 95%CI=0.1-0.8; p=0.036). Thus, GJA5 gene rs35594137 polymorphism is significantly associated with sudden cardiac death in the examined group.

    Язык оригиналаанглийский
    Страницы (с-по)73-77
    Число страниц5
    ЖурналBulletin of Experimental Biology and Medicine
    Том163
    Номер выпуска1
    DOI
    СостояниеОпубликовано - 1 мая 2017

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