Architecture of Promoters of House-Keeping Genes in Polytene Chromosome Interbands of Drosophila melanogaster

Результат исследования: Научные публикации в периодических изданияхстатья

1 Цитирования (Scopus)

Аннотация

Abstract: This is the first study to investigate the molecular-genetic organization of polytene chromosome interbands located on both molecular and cytological maps of Drosophila genome. The majority of the studied interbands contained one gene with a single transcription initiation site; the remaining interbands contained one gene with several alternative promoters, two or more unidirectional genes, and “head-to-head” arranged genes. In addition, intricately arranged interbands containing three or more genes in both unidirectional and bidirectional orientation were found. Insulator proteins, ORC, P-insertions, DNase I hypersensitive sites, and other open chromatin structures were situated in the promoter region of the genes located in the interbands. This area is critical for the formation of the interband, an open chromatin region in which gene transcription and replication are combined.

Язык оригиналаанглийский
Страницы (с-по)95-100
Число страниц6
ЖурналDoklady Biochemistry and Biophysics
Том485
Номер выпуска1
DOI
СостояниеОпубликовано - 1 мар 2019

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