Application of silicon dioxide nanoparticles modified with tumor-targeting ligands for cellular delivery of nucleoside triphosphate analogues

Svetlana V. Vasilyeva, Albina S. Petrova, Alexander A. Shtil, Dmitry A. Stetsenko

Результат исследования: Научные публикации в периодических изданияхстатья

Выдержка

A key advantage of amino-modified SiO2 nanoparticles for delivery of phosphorylated nucleosides is a broad possibility for functionalization. It can be modified with ligands currently investigated in targeted drug delivery. To improve the efficacy for intracellular delivery, SiO2 nanoparticles were functionalized with tumor-targeting ligands folic acid, biotin or 5-fluorouracil. Studies of accumulation of these conjugates in HCT116 colon carcinoma cells revealed that the uptake of modified conjugates was significantly bigger compared to unmodified nanoparticles, with the biotinylated conjugate as the preferred compound. The nanocomposites of biotin modified SiO2 and 2′,3′-dideoxyuridine triphosphate showed a pronounced antiproliferative potency relative to the unmodified nanocomposites. Thus, multi-functionalization of SiO2 nanoparticle based conjugates has a major potential for delivery of nucleoside triphosphate analogues, therefore tentatively enhancing their bioactivity.

Язык оригиналаанглийский
Страницы (с-по)98-104
Число страниц7
ЖурналJournal of Saudi Chemical Society
Том24
Номер выпуска1
DOI
СостояниеОпубликовано - янв 2020

Отпечаток

Nucleosides
Silicon Dioxide
Tumors
Nanoparticles
Ligands
Biotin
Nanocomposites
Bioactivity
Folic Acid
Fluorouracil
Cells
triphosphoric acid

Цитировать

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abstract = "A key advantage of amino-modified SiO2 nanoparticles for delivery of phosphorylated nucleosides is a broad possibility for functionalization. It can be modified with ligands currently investigated in targeted drug delivery. To improve the efficacy for intracellular delivery, SiO2 nanoparticles were functionalized with tumor-targeting ligands folic acid, biotin or 5-fluorouracil. Studies of accumulation of these conjugates in HCT116 colon carcinoma cells revealed that the uptake of modified conjugates was significantly bigger compared to unmodified nanoparticles, with the biotinylated conjugate as the preferred compound. The nanocomposites of biotin modified SiO2 and 2′,3′-dideoxyuridine triphosphate showed a pronounced antiproliferative potency relative to the unmodified nanocomposites. Thus, multi-functionalization of SiO2 nanoparticle based conjugates has a major potential for delivery of nucleoside triphosphate analogues, therefore tentatively enhancing their bioactivity.",
keywords = "Colon cancer cells, Cycloaddition reaction, Phosphorylated nucleoside analogues, SiO nanoparticles, Tumor-targeting ligands",
author = "Vasilyeva, {Svetlana V.} and Petrova, {Albina S.} and Shtil, {Alexander A.} and Stetsenko, {Dmitry A.}",
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Application of silicon dioxide nanoparticles modified with tumor-targeting ligands for cellular delivery of nucleoside triphosphate analogues. / Vasilyeva, Svetlana V.; Petrova, Albina S.; Shtil, Alexander A.; Stetsenko, Dmitry A.

В: Journal of Saudi Chemical Society, Том 24, № 1, 01.2020, стр. 98-104.

Результат исследования: Научные публикации в периодических изданияхстатья

TY - JOUR

T1 - Application of silicon dioxide nanoparticles modified with tumor-targeting ligands for cellular delivery of nucleoside triphosphate analogues

AU - Vasilyeva, Svetlana V.

AU - Petrova, Albina S.

AU - Shtil, Alexander A.

AU - Stetsenko, Dmitry A.

PY - 2020/1

Y1 - 2020/1

N2 - A key advantage of amino-modified SiO2 nanoparticles for delivery of phosphorylated nucleosides is a broad possibility for functionalization. It can be modified with ligands currently investigated in targeted drug delivery. To improve the efficacy for intracellular delivery, SiO2 nanoparticles were functionalized with tumor-targeting ligands folic acid, biotin or 5-fluorouracil. Studies of accumulation of these conjugates in HCT116 colon carcinoma cells revealed that the uptake of modified conjugates was significantly bigger compared to unmodified nanoparticles, with the biotinylated conjugate as the preferred compound. The nanocomposites of biotin modified SiO2 and 2′,3′-dideoxyuridine triphosphate showed a pronounced antiproliferative potency relative to the unmodified nanocomposites. Thus, multi-functionalization of SiO2 nanoparticle based conjugates has a major potential for delivery of nucleoside triphosphate analogues, therefore tentatively enhancing their bioactivity.

AB - A key advantage of amino-modified SiO2 nanoparticles for delivery of phosphorylated nucleosides is a broad possibility for functionalization. It can be modified with ligands currently investigated in targeted drug delivery. To improve the efficacy for intracellular delivery, SiO2 nanoparticles were functionalized with tumor-targeting ligands folic acid, biotin or 5-fluorouracil. Studies of accumulation of these conjugates in HCT116 colon carcinoma cells revealed that the uptake of modified conjugates was significantly bigger compared to unmodified nanoparticles, with the biotinylated conjugate as the preferred compound. The nanocomposites of biotin modified SiO2 and 2′,3′-dideoxyuridine triphosphate showed a pronounced antiproliferative potency relative to the unmodified nanocomposites. Thus, multi-functionalization of SiO2 nanoparticle based conjugates has a major potential for delivery of nucleoside triphosphate analogues, therefore tentatively enhancing their bioactivity.

KW - Colon cancer cells

KW - Cycloaddition reaction

KW - Phosphorylated nucleoside analogues

KW - SiO nanoparticles

KW - Tumor-targeting ligands

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