Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells

T. S. Frolova, A. V. Lipeeva, D. S. Baev, Y. A. Tsepilov, O. I. Sinitsyna

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

2 Цитирования (Scopus)


Pentacyclic triterpene acids are of great interest as compounds that exhibit selective cytotoxicity against malignant tumor cells. If earlier studies were carried out mainly in cancer cells of epithelial origin, in the present work the cytotoxic effect of ursolic and pomolic acids on the primary and permanent glioma cell lines was analyzed. Both compounds are toxic to oncotransformed cells and induce apoptosis in U-87 MG line. Using molecular docking, it has been shown that Akt1 and MDM2 may be potential targets of the studied triterpene acids. It has been suggested that ursolic and pomolic acids induce apoptosis in glioma cells through inhibition of the PI3K/Akt signaling pathway, and they can be considered as potentially promising agents for the treatment of glioblastoma.

Язык оригиналаанглийский
Страницы (с-по)809-816
Число страниц8
ЖурналMolekuliarnaia biologiia
Номер выпуска5
СостояниеОпубликовано - 1 сент. 2017

Ключевые слова

  • Apoptosis/drug effects
  • Cell Line, Tumor
  • Cytotoxins/chemistry
  • Glioma/drug therapy
  • Humans
  • Molecular Docking Simulation
  • Oleanolic Acid/analogs & derivatives
  • Proto-Oncogene Proteins c-akt/chemistry
  • Proto-Oncogene Proteins c-mdm2/chemistry
  • Signal Transduction/drug effects
  • Triterpenes/chemistry


Подробные сведения о темах исследования «Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells». Вместе они формируют уникальный семантический отпечаток (fingerprint).