Antiulcerogenic activity of borneol derivatives

M. S. Borisova; O. I. Yarovaya; M. D. Semenova; T. G. Tolstikova; N. F. Salakhutdinov

doi:10.1007/s11172-018-2110-y

Antiulcerogenic activity of borneol derivatives

M. S. Borisova, O. I. Yarovaya, M. D. Semenova, T. G. Tolstikova, N. F. Salakhutdinov

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

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Аннотация

Antiulcerogenic activity of borneol and its N-heterocyclic esters was investigated using indomethacin-induced gastric ulcer model. A considerable antiulcerogenic effect comparable to that shown by Omeprazole and Famotidine was found for two investigated compounds in the indomethacin-induced gastric ulcer model. Bornyl 2-piperazinoacetate, with a non-substituted piperazine moiety, showed maximum antiulcerogenic activity in the indomethacininduced gastric ulcer model and demonstrated a significant gastroprotective effect in the ethanol-induced gastric ulcer model comparable to the effect of Omeprazole.

Язык оригинала	английский
Страницы (с-по)	558-561
Число страниц	4
Журнал	Russian Chemical Bulletin
Том	67
Номер выпуска	3
DOI	https://doi.org/10.1007/s11172-018-2110-y
Состояние	Опубликовано - 1 мар. 2018

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10.1007/s11172-018-2110-y

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abstract = "Antiulcerogenic activity of borneol and its N-heterocyclic esters was investigated using indomethacin-induced gastric ulcer model. A considerable antiulcerogenic effect comparable to that shown by Omeprazole and Famotidine was found for two investigated compounds in the indomethacin-induced gastric ulcer model. Bornyl 2-piperazinoacetate, with a non-substituted piperazine moiety, showed maximum antiulcerogenic activity in the indomethacininduced gastric ulcer model and demonstrated a significant gastroprotective effect in the ethanol-induced gastric ulcer model comparable to the effect of Omeprazole.",

keywords = "antiulcerogenic activity, borneol derivatives",

author = "Borisova, {M. S.} and Yarovaya, {O. I.} and Semenova, {M. D.} and Tolstikova, {T. G.} and Salakhutdinov, {N. F.}",

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T1 - Antiulcerogenic activity of borneol derivatives

AU - Borisova, M. S.

AU - Yarovaya, O. I.

AU - Semenova, M. D.

AU - Tolstikova, T. G.

AU - Salakhutdinov, N. F.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Antiulcerogenic activity of borneol and its N-heterocyclic esters was investigated using indomethacin-induced gastric ulcer model. A considerable antiulcerogenic effect comparable to that shown by Omeprazole and Famotidine was found for two investigated compounds in the indomethacin-induced gastric ulcer model. Bornyl 2-piperazinoacetate, with a non-substituted piperazine moiety, showed maximum antiulcerogenic activity in the indomethacininduced gastric ulcer model and demonstrated a significant gastroprotective effect in the ethanol-induced gastric ulcer model comparable to the effect of Omeprazole.

AB - Antiulcerogenic activity of borneol and its N-heterocyclic esters was investigated using indomethacin-induced gastric ulcer model. A considerable antiulcerogenic effect comparable to that shown by Omeprazole and Famotidine was found for two investigated compounds in the indomethacin-induced gastric ulcer model. Bornyl 2-piperazinoacetate, with a non-substituted piperazine moiety, showed maximum antiulcerogenic activity in the indomethacininduced gastric ulcer model and demonstrated a significant gastroprotective effect in the ethanol-induced gastric ulcer model comparable to the effect of Omeprazole.

KW - antiulcerogenic activity

KW - borneol derivatives

UR - http://www.scopus.com/inward/record.url?scp=85049339495&partnerID=8YFLogxK

U2 - 10.1007/s11172-018-2110-y

DO - 10.1007/s11172-018-2110-y

M3 - Article

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SP - 558

EP - 561

JO - Russian Chemical Bulletin

JF - Russian Chemical Bulletin

SN - 1066-5285

IS - 3

ER -

Antiulcerogenic activity of borneol derivatives

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