Аннотация
We propose an original method for controlling BP by administration of Si~ODN nanocomposites containing antisense oligonucleotides fixed on silicon-organic nanoparticles. ODN in nanocomposites are targeted to mRNA of the genes encoding angiotensin-converting enzyme (ACE1) and type 1 angiotensin-II receptor (AT1A). The experiments were performed on hypertensive ISIAH rats, a genetic model of hypertension. Single inhalation or intraperitoneal administration of the nanocomposites targeted to ACE1 mRNA or ATA1 mRNA, respectively, led to a pronounced decrease (by ~30 mm Hg) in systolic BP in ISIAH rats over a week. The use of scrambled ODN in the nanocomposites had no effect. A decrease in the expression of ACE1 and AT1A genes under the effect of the corresponding antisense ODN was demonstrated, which attested to directed effect of the test preparations.
Язык оригинала | английский |
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Страницы (с-по) | 116-119 |
Число страниц | 4 |
Журнал | Bulletin of Experimental Biology and Medicine |
Том | 167 |
Номер выпуска | 1 |
DOI | |
Состояние | Опубликовано - 15 мая 2019 |
Предметные области OECD FOS+WOS
- 3.01.QA МЕДИЦИНА, ИССЛЕДОВАТЕЛЬСКАЯ И ЭКСПЕРИМЕНТАЛЬНАЯ
- 1.06 БИОЛОГИЧЕСКИЕ НАУКИ