Antisense Oligonucleotides Immobilized on Silicon-Organic Nanoparticles as a Tool for Prolonged Correction of Hypertensive States

A. S. Levina, M. N. Repkova, L. O. Klimov, M. A. Ryazanova, A. L. Markel, V. F. Zarytova

Результат исследования: Научные публикации в периодических изданияхстатья

Аннотация

We propose an original method for controlling BP by administration of Si~ODN nanocomposites containing antisense oligonucleotides fixed on silicon-organic nanoparticles. ODN in nanocomposites are targeted to mRNA of the genes encoding angiotensin-converting enzyme (ACE1) and type 1 angiotensin-II receptor (AT1A). The experiments were performed on hypertensive ISIAH rats, a genetic model of hypertension. Single inhalation or intraperitoneal administration of the nanocomposites targeted to ACE1 mRNA or ATA1 mRNA, respectively, led to a pronounced decrease (by ~30 mm Hg) in systolic BP in ISIAH rats over a week. The use of scrambled ODN in the nanocomposites had no effect. A decrease in the expression of ACE1 and AT1A genes under the effect of the corresponding antisense ODN was demonstrated, which attested to directed effect of the test preparations.

Язык оригиналаанглийский
Страницы (с-по)116-119
Число страниц4
ЖурналBulletin of Experimental Biology and Medicine
Том167
Номер выпуска1
DOI
СостояниеОпубликовано - 15 мая 2019

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