Antioxidative properties of nitroxyl radicals and hydroxyamines in reactions with triplet and deaminated kynurenine

Vadim Yanshole, I. A. Kirilyuk, I. A. Grigor'ev, S. V. Morozov, Yu. P. Tsentalovicha

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

11 Цитирования (Scopus)

Аннотация

The reactions of triplet kynurenine and 4-(2-aminophenyl)-4-oxocrotonic acid, formed upon the thermal decomposition of kynurenine, with nitroxyl radicals and cyclic N-hydroxylamines were studied. Nitroxyl radicals were found to quench efficiently the triplet state of kynurenine (rate constant 3-6 center dot.10(8) L mol(-1) s(-1)). The quenching proceeds via the spin-exchange mechanism and affords no new products. Neither nitroxyl radicals, nor hydroxyl-lamines react with 4-(2-aminophenyl)-4-oxocrotonic acid under conditions similar to physiological.

Язык оригиналаанглийский
Страницы (с-по)66-74
Число страниц9
ЖурналRussian Chemical Bulletin
Том59
Номер выпуска1
DOI
СостояниеОпубликовано - янв 2010

Предметные области OECD FOS+WOS

  • 1.04 ХИМИЧЕСКИЕ НАУКИ

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