Anti-Influenza Activity of Medicinal Material Extracts from Qinghai–Tibet Plateau

Olga Kurskaya, Elena Prokopyeva, Hongtao Bi, Ivan Sobolev, Tatyana Murashkina, Alexander Shestopalov, Lixin Wei, Kirill Sharshov

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

Аннотация

To discover sources for novel anti-influenza drugs, we evaluated the antiviral potential of nine extracts from eight medicinal plants and one mushroom (Avena sativa L., Hordeum vulgare Linn. var. nudum Hook. f., Hippophae rhamnoides Linn., Lycium ruthenicum Murr., Nitraria tangutorum Bobr., Nitraria tangutorum Bobr. by-products, Potentilla anserina L., Cladina rangiferina (L.) Nyl., and Armillaria luteo-virens) from the Qinghai–Tibetan plateau against the influenza A/H3N2 virus. Concentrations lower than 125 µg/mL of all extracts demonstrated no significant toxicity in MDCK cells. During screening, seven extracts (A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens) exhibited antiviral activity, especially the water-soluble polysaccharide from the fruit body of the mushroom A. luteo-virens. These extracts significantly reduced the infec-tivity of the human influenza A/H3N2 virus in vitro when used at concentrations of 15.6–125 µg/mL. Two extracts (N. tangutorum by-products and P. anserina) had no A/H3N2 virus inhibitory activ-ity. Notably, the extract obtained from the fruits of N. tangutorum and N. tangutorum by-products exhibited different anti-influenza effects. The results suggest that extracts of A. sativa, H. vulgare, H. rhamnoides, L. ruthenicum, N. tangutorum, C. rangiferina, and A. luteo-virens contain substances with antiviral activity, and may be promising sources of new antiviral drugs.

Язык оригиналаанглийский
Номер статьи360
ЖурналViruses
Том14
Номер выпуска2
DOI
СостояниеОпубликовано - февр. 2022

Предметные области OECD FOS+WOS

  • 1.06.ZE ВИРУСОЛОГИЯ

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