Anti-inflammatory and cell proliferative effect of the 1270 nm laser irradiation on the BALB/c nude mouse model involves activation of the cell antioxidant system

Dinara Dolgova, Tatiana Abakumova, Tatiana Gening, Ludmila Poludnyakova, Igor Zolotovskii, Dmitrii Stoliarov, Andrei Fotiadi, Anna Khokhlova, Edik Rafailov, Sergei Sokolovski

Результат исследования: Научные публикации в периодических изданияхстатья


Recently, many interdisciplinary community researchers have focused their efforts on study of the low-level light irradiation effects (photobiomodulation, PBM) as a promising therapeutic technology. Among the priorities, a search of new wavelength ranges of laser radiation to enhance the laser prospects in treatment of autoimmune and cancer diseases commonly accompanied by disorders in the antioxidant system of the body. The laser wavelengths within 1265-1270 nm corresponds to the maximum oxygen absorption band. Therefore, PBM effects on a model organism within this spectrum range are of particular interest for preclinical research. Here, we report comprehensive biomolecular studies of the changes in the BALB/c nude mice skin after an exposure to the continuous laser radiation at the 1270 nm wavelength and energy densities of 0.12 and 1.2 J/cm2. Such regime induces both local and systemic PBM effects, presumably due to the short-term increase in ROS levels, which in turn activate the cell antioxidative system.

Язык оригиналаанглийский
Номер статьи363565
Страницы (с-по)4261-4275
Число страниц15
ЖурналBiomedical Optics Express
Номер выпуска8
СостояниеОпубликовано - 1 авг 2019