TY - JOUR
T1 - Analysis of grounded substrate effects on cold atmospheric plasma jet irradiation of cellular and animal models
AU - Schweigert, I.
AU - Alexandrov, A.
AU - Zakrevsky, D.
AU - Gugin, P.
AU - Milakhina, E.
AU - Golubitskaya, E.
AU - Troitskaya, O.
AU - Biryukov, M.
AU - Koval, O.
N1 - Funding Information:
The authors gratefully acknowledge financial support from Russian Science Foundation, grant N 19-19-00255. The authors, EM and Dm Z, were partly supported financially by RFBR grant N 18-08-00510 for development of various designs of experimental setup.
Publisher Copyright:
© 2020 Institute of Physics Publishing. All rights reserved.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/12/31
Y1 - 2020/12/31
N2 - Plasma devices with cylindrical and plane geometries generating the nonthermal atmospheric plasma jets are used for the treatment of the cancer cells in vitro and in vivo. It is shown in the simulations and experiment that the grounded substrate placed under the bio target essentially increases the plasma treatment efficiency. Nevertheless the temperature control is needed to avoid the burns in a spot of contact of plasma jet with the mice skin. The measured and calculated local temperature increase with different regimes of plasma device operation is presented. The MTT and iCELLigence assays of the viability of cancer cells in vitro show the efficiency of plasma jet treatment and mice models in vivo demonstrate the safety regime for cold atmospheric pressure plasma irradiation.
AB - Plasma devices with cylindrical and plane geometries generating the nonthermal atmospheric plasma jets are used for the treatment of the cancer cells in vitro and in vivo. It is shown in the simulations and experiment that the grounded substrate placed under the bio target essentially increases the plasma treatment efficiency. Nevertheless the temperature control is needed to avoid the burns in a spot of contact of plasma jet with the mice skin. The measured and calculated local temperature increase with different regimes of plasma device operation is presented. The MTT and iCELLigence assays of the viability of cancer cells in vitro show the efficiency of plasma jet treatment and mice models in vivo demonstrate the safety regime for cold atmospheric pressure plasma irradiation.
UR - http://www.scopus.com/inward/record.url?scp=85099569317&partnerID=8YFLogxK
U2 - 10.1088/1742-6596/1698/1/012010
DO - 10.1088/1742-6596/1698/1/012010
M3 - Conference article
AN - SCOPUS:85099569317
VL - 1698
JO - Journal of Physics: Conference Series
JF - Journal of Physics: Conference Series
SN - 1742-6588
IS - 1
M1 - 012010
T2 - 19th International Workshop on Magneto-Plasma Aerodynamics, WSMPA 2020
Y2 - 15 September 2020 through 17 September 2020
ER -