Aliphatic and alicyclic camphor imines as effective inhibitors of influenza virus H1N1

Anastasiya S. Sokolova, Оlga I. Yarovaya, Dmitry S. Baev, Аndrey V. Shernyukov, Anna A. Shtro, Vladimir V. Zarubaev, Nariman F. Salakhutdinov

Результат исследования: Научные публикации в периодических изданияхстатья

20 Цитирования (Scopus)

Аннотация

A series of camphor derived imines was synthesised and evaluated in vitro for antiviral activity. Theoretical evaluations of ADME properties were also carried out. Most of these compounds exhibited significant activity against the drug-resistant strains of influenza A virus. Especially, compounds 2 (SI = 632) and 3 (SI = 417) presented high inhibition against influenza subtypes A/Puerto Rico/8/34 and A/California/07/09 of H1N1pdm09. Analysis of the structure-activity relationship showed that the activity was strongly dependent on the length of the aliphatic chain: derivatives with a shorter chain possessed higher activity, while the suppressing action of compounds with long aliphatic chains was lower.

Язык оригиналаанглийский
Страницы (с-по)661-670
Число страниц10
ЖурналEuropean Journal of Medicinal Chemistry
Том127
DOI
СостояниеОпубликовано - 15 фев 2017

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