@article{d922dfc0390a46318b4cbe43b0c99512,
title = "A versatile strategy for the design and synthesis of novel ADP conjugates and their evaluation as potential poly(ADP-ribose) polymerase 1 inhibitors",
abstract = "Abstract: A versatile strategy for the synthesis of NAD + mimetics was developed, involving an efficient pyrophosphate linkage formation in key conjugates containing a functional amino group which acts as useful reactive anchor for further derivatization. These NAD + mimetics consist of ADP conjugated through a diphosphate chain to an extended aliphatic linker bearing an aromatic acid residue. A number of conjugates containing aromatic carboxylic acids were found to inhibit poly(ADP-ribose) synthesis catalyzed by poly(ADP-ribose) polymerase-1 (PARP-1). A new class of potential PARP-1 inhibitors mimicking NAD +, a substrate in the PARP-1 catalyzed reaction, was proposed.",
keywords = "NAD analogues, PARP inhibitors, PARP-1, Pyrophosphate synthesis, NAD/chemistry, Poly (ADP-Ribose) Polymerase-1/antagonists & inhibitors, Chemistry Techniques, Synthetic, Biomimetic Materials/chemical synthesis, Drug Design, Adenosine Diphosphate/chemistry, Enzyme Inhibitors/chemical synthesis, ACID, CHROMATIN, NICOTINAMIDE, PROBING BINDING REQUIREMENTS, STRUCTURAL-ANALYSIS, FUNCTIONALIZATION, REPAIR, DNA, NAD ANALOGS, NAD(+) analogues, PARP INHIBITORS",
author = "Sherstyuk, {Yuliya V.} and Zakharenko, {Alexandra L.} and Kutuzov, {Mikhail M.} and Chalova, {Polina V.} and Sukhanova, {Maria V.} and Lavrik, {Olga I.} and Silnikov, {Vladimir N.} and Abramova, {Tatyana V.}",
note = "Publisher Copyright: {\textcopyright} 2016, Springer International Publishing Switzerland.",
year = "2017",
month = feb,
day = "1",
doi = "10.1007/s11030-016-9703-x",
language = "English",
volume = "21",
pages = "101--113",
journal = "Molecular Diversity",
issn = "1381-1991",
publisher = "Springer Netherlands",
number = "1",
}