Аннотация
N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.
Язык оригинала | английский |
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Страницы | 134-135 |
Число страниц | 2 |
DOI | |
Состояние | Опубликовано - 2020 |
Событие | Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia) - ICG SB RAS, Новосибирск, Российская Федерация Продолжительность: 6 июл 2020 → 10 июл 2020 Номер конференции: 12 https://bgrssb.icgbio.ru/2020/ |
Конференция
Конференция | Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia) |
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Сокращенный заголовок | BGRS/SB-2020 |
Страна | Российская Федерация |
Город | Новосибирск |
Период | 06.07.2020 → 10.07.2020 |
Адрес в сети Интернет |