A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases

Olga O. Zaitseva; Gordan Lauc; Содбо Жамбалович Шарапов; Яков Александрович Цепилов; Lucija Klarić

doi:10.18699/BGRS/SB-2020-085

Аннотация

N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.

Язык оригинала	английский
Страницы	134-135
Число страниц	2
DOI	https://doi.org/10.18699/BGRS/SB-2020-085
Состояние	Опубликовано - 2020
Событие	Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia) - ICG SB RAS, Новосибирск, Российская Федерация Продолжительность: 6 июл 2020 → 10 июл 2020 Номер конференции: 12 https://bgrssb.icgbio.ru/2020/

Конференция

Конференция	Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia)
Сокращенный заголовок	BGRS/SB-2020
Страна	Российская Федерация
Город	Новосибирск
Период	06.07.2020 → 10.07.2020
Адрес в сети Интернет	https://bgrssb.icgbio.ru/2020/

Доступ к документу

10.18699/BGRS/SB-2020-085

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Цитировать

Zaitseva, O. O., Lauc, G., Шарапов, С. Ж., Цепилов, Я. А., & Klarić, L. (2020). A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases. 134-135. Выдержка из Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Российская Федерация. https://doi.org/10.18699/BGRS/SB-2020-085

Zaitseva, Olga O. ; Lauc, Gordan ; Шарапов, Содбо Жамбалович ; Цепилов, Яков Александрович ; Klarić, Lucija. / A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases. Выдержка из Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Российская Федерация.2 стр.

@conference{14ea0449e9ec463692c44345e2e2f69e,

title = "A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases",

abstract = "N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.",

author = "Zaitseva, {Olga O.} and Gordan Lauc and Шарапов, {Содбо Жамбалович} and Цепилов, {Яков Александрович} and Lucija Klari{\'c}",

note = "The work of OOZ and GL was supported by the Croatian National Centre of Research Excellence in Personalized Healthcare grant (#KK.01.1.1.01.0010). The work of SZSh was supported by the Russian Science Foundation grant number 19-15-00115. The work of LK was supported by the RCUK Innovation Fellowship from the National Productivity Investment Fund (MR/R026408/1).The work of YAT was supported by the Russian Ministry of Science and Education under the 5-100 Excellence Programme by the Federal Agency of Scientific Organizations via the Institute of Cytology and Genetics (project 0324-2019-0040-C- 01/АААА-А17-117092070032-4).; null ; Conference date: 06-07-2020 Through 10-07-2020",

year = "2020",

doi = "10.18699/BGRS/SB-2020-085",

language = "English",

pages = "134--135",

url = "https://bgrssb.icgbio.ru/2020/",

}

Zaitseva, OO, Lauc, G, Шарапов, СЖ , Цепилов, ЯА & Klarić, L 2020, 'A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases', Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Российская Федерация, 06.07.2020 - 10.07.2020 стр. 134-135. https://doi.org/10.18699/BGRS/SB-2020-085

A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases. / Zaitseva, Olga O.; Lauc, Gordan; Шарапов, Содбо Жамбалович ; Цепилов, Яков Александрович; Klarić, Lucija.

2020. 134-135 Выдержка из Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Российская Федерация.

Результат исследования: Материалы конференций › тезисы › рецензирование

TY - CONF

T1 - A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases

AU - Zaitseva, Olga O.

AU - Lauc, Gordan

AU - Шарапов, Содбо Жамбалович

AU - Цепилов, Яков Александрович

AU - Klarić, Lucija

N1 - Conference code: 12

PY - 2020

Y1 - 2020

N2 - N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.

AB - N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.

UR - https://www.elibrary.ru/item.asp?id=44042203

U2 - 10.18699/BGRS/SB-2020-085

DO - 10.18699/BGRS/SB-2020-085

M3 - Abstract

SP - 134

EP - 135

Y2 - 6 July 2020 through 10 July 2020

ER -

Zaitseva OO, Lauc G, Шарапов СЖ , Цепилов ЯА, Klarić L. A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases. 2020. Выдержка из Bioinformatics of Genome Regulation and Structure Systems Biology (BGRS/SB-2020): The Twelfth International Multiconference (06-10 July 2020, Novosibirsk, Russia), Новосибирск, Российская Федерация. https://doi.org/10.18699/BGRS/SB-2020-085