A study of causal relationships between human IgG N-glycosylation traits and twelve associated diseases

Olga O. Zaitseva, Sodbo Z. Sharapov, Lucija Klaric, Gordan Lauc, Yakov A. Tsepilov

Результат исследования: Научные публикации в периодических изданияхтезисырецензирование

Аннотация

N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.
Язык оригиналаанглийский
Страницы (с-по)1132-1132
Число страниц1
ЖурналGlycobiology
Том30
Номер выпуска12
СостояниеОпубликовано - дек 2020

Предметные области OECD FOS+WOS

  • 1.06 БИОЛОГИЧЕСКИЕ НАУКИ

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