Аннотация
N-glycosylation of IgG affects ligand binding, antigen recognition and modulates immune response. IgG N- glycome is altered in many pathological states, including cancers, autoimmune and inflammatory diseases. However, the causal relationships between diseases and IgG N-glycosylation traits remain enigmatic. In the current study we implement a Mendelian Randomization approach to study causal effect of IgG N-glycan traits on 12 diseases and vice versa. We have found limited genetic evidence that increased risk of systemic lupus erythematosus might lead to increased bisection of IgG N- glycans.
Язык оригинала | английский |
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Страницы (с-по) | 1132-1132 |
Число страниц | 1 |
Журнал | Glycobiology |
Том | 30 |
Номер выпуска | 12 |
Состояние | Опубликовано - дек 2020 |