A new structure of a serotonin salt: Comparison and conformational analysis of all known serotonin complexes

Denis Rychkov; Elena V. Boldyreva; Nikolay A. Tumanov

doi:10.1107/S0108270113019823

A new structure of a serotonin salt: Comparison and conformational analysis of all known serotonin complexes

Denis Rychkov, Elena V. Boldyreva, Nikolay A. Tumanov

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

7 Цитирования (Scopus)

Аннотация

Four serotonin salt structures (serotonin adipate, C₁₀H ₁₃N₂O⁺·C₆H₉O ₄ ^-, is a previously unknown structure) were analysed to understand the influence of the anion on serotonin conformation. Hydrogen bonding alone favours a flat conformation, whereas additional stacking interactions between ions may possibly account for the nonplanar conformation. Since molecular conformation, stability and biological activity are interrelated, one can consider influencing the chemical and biological properties of serotonin by selecting an appropriate counter-ion for salt formation.

Язык оригинала	английский
Страницы (с-по)	1055-1061
Число страниц	7
Журнал	Acta Crystallographica Section C: Crystal Structure Communications
Том	69
Номер выпуска	9
DOI	https://doi.org/10.1107/S0108270113019823
Состояние	Опубликовано - сен 2013

Доступ к документу

10.1107/S0108270113019823

Ссылка на публикацию в Scopus

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Цитировать

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abstract = "Four serotonin salt structures (serotonin adipate, C10H 13N2O+·C6H9O 4 -, is a previously unknown structure) were analysed to understand the influence of the anion on serotonin conformation. Hydrogen bonding alone favours a flat conformation, whereas additional stacking interactions between ions may possibly account for the nonplanar conformation. Since molecular conformation, stability and biological activity are interrelated, one can consider influencing the chemical and biological properties of serotonin by selecting an appropriate counter-ion for salt formation.",

keywords = "conformation, crystal structure, Hirshfeld surfaces, hydrogen bonding, serotonin adipate, stacking interactions",

author = "Denis Rychkov and Boldyreva, {Elena V.} and Tumanov, {Nikolay A.}",

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A new structure of a serotonin salt : Comparison and conformational analysis of all known serotonin complexes. / Rychkov, Denis ; Boldyreva, Elena V.; Tumanov, Nikolay A.

В: Acta Crystallographica Section C: Crystal Structure Communications, Том 69, № 9, 09.2013, стр. 1055-1061.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

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