A Monolithic Column with a Sorbent Based on 1-Vinyl-1,2,4-Triazole for Hydrophilic HPLC

Yu V. Patrushev; Yu S. Sotnikova; V. N. Sidel’nikov

doi:10.1134/S2070205119060248

A Monolithic Column with a Sorbent Based on 1-Vinyl-1,2,4-Triazole for Hydrophilic HPLC

Yu V. Patrushev, Yu S. Sotnikova, V. N. Sidel’nikov

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

Аннотация

Abstract: A monolithic chromatographic column for HPLC with a sorbent based on 1-vinyl-1,2,4-triazole has been prepared for the first time. It has been shown that, depending on the composition of the mobile phase (acetonitrile/water ratio), this column is able to operate in the modes of both reverse phase chromatography and hydrophilic chromatography. The dependences of the retention factor on the volume fraction of acetonitrile in the mobile phase have been studied for substances of acidic and basic nature. An example of the separation of the components of the pharmaceutical product Askofen-P on the prepared column has been provided.

Язык оригинала	английский
Страницы (с-по)	49-53
Число страниц	5
Журнал	Protection of Metals and Physical Chemistry of Surfaces
Том	56
Номер выпуска	1
DOI	https://doi.org/10.1134/S2070205119060248
Состояние	Опубликовано - янв. 2020

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10.1134/S2070205119060248

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title = "A Monolithic Column with a Sorbent Based on 1-Vinyl-1,2,4-Triazole for Hydrophilic HPLC",

abstract = "Abstract: A monolithic chromatographic column for HPLC with a sorbent based on 1-vinyl-1,2,4-triazole has been prepared for the first time. It has been shown that, depending on the composition of the mobile phase (acetonitrile/water ratio), this column is able to operate in the modes of both reverse phase chromatography and hydrophilic chromatography. The dependences of the retention factor on the volume fraction of acetonitrile in the mobile phase have been studied for substances of acidic and basic nature. An example of the separation of the components of the pharmaceutical product Askofen-P on the prepared column has been provided.",

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author = "Patrushev, {Yu V.} and Sotnikova, {Yu S.} and Sidel{\textquoteright}nikov, {V. N.}",

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A Monolithic Column with a Sorbent Based on 1-Vinyl-1,2,4-Triazole for Hydrophilic HPLC. / Patrushev, Yu V.; Sotnikova, Yu S.; Sidel’nikov, V. N.

В: Protection of Metals and Physical Chemistry of Surfaces, Том 56, № 1, 01.2020, стр. 49-53.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

TY - JOUR

T1 - A Monolithic Column with a Sorbent Based on 1-Vinyl-1,2,4-Triazole for Hydrophilic HPLC

AU - Patrushev, Yu V.

AU - Sotnikova, Yu S.

AU - Sidel’nikov, V. N.

PY - 2020/1

Y1 - 2020/1

N2 - Abstract: A monolithic chromatographic column for HPLC with a sorbent based on 1-vinyl-1,2,4-triazole has been prepared for the first time. It has been shown that, depending on the composition of the mobile phase (acetonitrile/water ratio), this column is able to operate in the modes of both reverse phase chromatography and hydrophilic chromatography. The dependences of the retention factor on the volume fraction of acetonitrile in the mobile phase have been studied for substances of acidic and basic nature. An example of the separation of the components of the pharmaceutical product Askofen-P on the prepared column has been provided.

AB - Abstract: A monolithic chromatographic column for HPLC with a sorbent based on 1-vinyl-1,2,4-triazole has been prepared for the first time. It has been shown that, depending on the composition of the mobile phase (acetonitrile/water ratio), this column is able to operate in the modes of both reverse phase chromatography and hydrophilic chromatography. The dependences of the retention factor on the volume fraction of acetonitrile in the mobile phase have been studied for substances of acidic and basic nature. An example of the separation of the components of the pharmaceutical product Askofen-P on the prepared column has been provided.

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KW - hydrophilic interaction chromatography

KW - monolithic columns

KW - porous polymers

KW - ROD COLUMNS

KW - 4-triazole

KW - ACID

KW - CAPILLARY COLUMNS

KW - 2

KW - 1-vinyl-1

KW - POLYMER

KW - SEPARATION

KW - SELECTIVITY

KW - INTERACTION CHROMATOGRAPHY

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DO - 10.1134/S2070205119060248

M3 - Article

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JO - Protection of Metals and Physical Chemistry of Surfaces

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