A fatal case of tick-borne rickettsiosis caused by mixed Rickettsia sibirica subsp. sibirica and “Candidatus Rickettsia tarasevichiae” infection in Russia

Nikolay Rudakov, I. Samoylenko, Sergey Shtrek, Yana Igolkina, Vera Rar, E. Zhirakovskaia, Sergey Tkachev, Tatiana Kostrykina, Inga Blokhina, Petr Lentz, Nina Tikunova

Результат исследования: Научные публикации в периодических изданияхстатьярецензирование

1 Цитирования (Scopus)

Аннотация

North Asian tick-typhus (NATT), also known as Siberian tick typhus, is the main tick-borne rickettsiosis in Siberia, Russia. Recently, a fatal infection in a four-year-old girl with typical tick-borne rickettsiosis symptoms (fever, rash, eschar at the site of the tick bite, myalgia) and meningeal syndrome was registered. In order to identify the etiology of this infection, blood and brain samples from the patient were examined for the presence of a wide range of tick-transmitted agents and enteric viruses by polymerase chain reaction with subsequent sequencing. Rickettsia sibirica subsp. sibirica and “Candidatus Rickettsia tarasevichiae” DNA was identified in both blood and brain samples. Rickettsia sibirica was characterized by the gltA, ompA and ompB genes, and “Candidatus R. tarasevichiae” was characterized by the gltA and ompB genes. We report the first case of mixed R. sibirica and “Candidatus R. tarasevichiae” human infection with a fatal outcome in Russia.

Язык оригиналаанглийский
Номер статьи101278
ЖурналTicks and Tick-borne Diseases
Том10
Номер выпуска6
DOI
СостояниеОпубликовано - окт 2019
Опубликовано для внешнего пользованияДа

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