A facile approach to 6-amino-2H-pyrano[2,3-g]isoquinolin-2-ones via a sequential Sonogashira coupling of 6-cyanoumbelliferone triflate and annulations with amines

Alla V. Lipeeva, Makhmut M. Shakirov, Elvira E. Shults

    Результат исследования: Научные публикации в периодических изданияхстатья

    Аннотация

    Palladium-catalyzed synthesis of 2H-pyrano[2,3-g]isoquinolinones have been described from easily accessible precursor 6-cyanoumbelliferone triflate via sequential of Sonogashira coupling and the following annulations with several primary alkylamines under basic conditions The so obtained 6-propargylamino-2H-pyrano[2,3-g]isoquinolinones were involved in the CuAAC reaction with 2-azidobenzoic acid for obtaining 2H-pyrano[2,3-g]isoquinoline-benzoic acid hybrid compounds containing a 1,2,3-triazole linker.

    Язык оригиналаанглийский
    Страницы (с-по)3301-3310
    Число страниц10
    ЖурналSynthetic Communications
    Том49
    Номер выпуска23
    DOI
    СостояниеОпубликовано - 2 дек 2019

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