A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity

Anna A. Krasilnikova; Anastasiya O. Solovieva; Anton A. Ivanov; Konstantin A. Brylev; Tatiana N. Pozmogova; Marina A. Gulyaeva; Olga G. Kurskaya; Alexander Y. Alekseev; Alexander M. Shestopalov; Lidiya V. Shestopalova; Alexander F. Poveshchenko; Olga A. Efremova; Yuri V. Mironov; Michael A. Shestopalov

doi:10.1039/c7tx00083a

A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity

Anna A. Krasilnikova, Anastasiya O. Solovieva, Anton A. Ivanov, Konstantin A. Brylev, Tatiana N. Pozmogova, Marina A. Gulyaeva, Olga G. Kurskaya, Alexander Y. Alekseev, Alexander M. Shestopalov, Lidiya V. Shestopalova, Alexander F. Poveshchenko, Olga A. Efremova, Yuri V. Mironov, Michael A. Shestopalov

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

12 Цитирования (Scopus)

Аннотация

The octahedral rhenium cluster compound Na₂H₈[{Re₆Se₈}(P(C₂H₄CONH₂)(C₂H₄COO)₂)₆] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to the difficulty in controlling the hydrolysis of the initial P(C₂H₄CN)₃ ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na₂H₈[{Re₆Se₈}(P(C₂H₄CONH₂)(C₂H₄COO)₂)₆] with those of related compounds featuring the fully hydrolysed form of the phosphine ligand, namely Na₂H₁₄[{Re₆Q₈}(P(C₂H₄COO)₃)₆] (Q = S or Se). Our results demonstrate that the cytotoxicity and acute in vivo toxicity of the complex Na₂H₈[{Re₆Se₈}(P(C₂H₄CONH₂)(C₂H₄COO)₂)₆] solutions were considerably lower than those of compounds with the fully hydrolysed ligand P(C₂H₄COOH)₃. Such behavior can be explained by the higher osmolality of Na₂H₁₄[{Re₆Q₈}(P(C₂H₄COO)₃)₆] versus Na₂H₈[{Re₆Se₈}(P(C₂H₄CONH₂)(C₂H₄COO)₂)₆].

Язык оригинала	английский
Страницы (с-по)	554-560
Число страниц	7
Журнал	Toxicology Research
Том	6
Номер выпуска	4
DOI	https://doi.org/10.1039/c7tx00083a
Состояние	Опубликовано - 1 июл. 2017

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10.1039/c7tx00083a

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Krasilnikova, A. A., Solovieva, A. O., Ivanov, A. A., Brylev, K. A., Pozmogova, T. N., Gulyaeva, M. A., Kurskaya, O. G., Alekseev, A. Y., Shestopalov, A. M., Shestopalova, L. V., Poveshchenko, A. F., Efremova, O. A., Mironov, Y. V., & Shestopalov, M. A. (2017). A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity. Toxicology Research, 6(4), 554-560. https://doi.org/10.1039/c7tx00083a

@article{0ff0b6b63fef467cb3a482921cf62e98,

title = "A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity",

abstract = "The octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to the difficulty in controlling the hydrolysis of the initial P(C2H4CN)3 ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] with those of related compounds featuring the fully hydrolysed form of the phosphine ligand, namely Na2H14[{Re6Q8}(P(C2H4COO)3)6] (Q = S or Se). Our results demonstrate that the cytotoxicity and acute in vivo toxicity of the complex Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] solutions were considerably lower than those of compounds with the fully hydrolysed ligand P(C2H4COOH)3. Such behavior can be explained by the higher osmolality of Na2H14[{Re6Q8}(P(C2H4COO)3)6] versus Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6].",

keywords = "CELLS, CELLULAR INTERNALIZATION, CHRONIC INFLAMMATION, CYTOTOXICITY, DISEASES, ENCAPSULATION, GOLD NANOPARTICLES, LUMINESCENCE, RAY CONTRAST AGENT, SILICA NANOPARTICLES",

author = "Krasilnikova, {Anna A.} and Solovieva, {Anastasiya O.} and Ivanov, {Anton A.} and Brylev, {Konstantin A.} and Pozmogova, {Tatiana N.} and Gulyaeva, {Marina A.} and Kurskaya, {Olga G.} and Alekseev, {Alexander Y.} and Shestopalov, {Alexander M.} and Shestopalova, {Lidiya V.} and Poveshchenko, {Alexander F.} and Efremova, {Olga A.} and Mironov, {Yuri V.} and Shestopalov, {Michael A.}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2017.",

year = "2017",

month = jul,

day = "1",

doi = "10.1039/c7tx00083a",

language = "English",

volume = "6",

pages = "554--560",

journal = "Toxicology Research",

issn = "2045-452X",

publisher = "Royal Society of Chemistry",

number = "4",

}

Krasilnikova, AA, Solovieva, AO, Ivanov, AA, Brylev, KA , Pozmogova, TN , Gulyaeva, MA, Kurskaya, OG, Alekseev, AY, Shestopalov, AM, Shestopalova, LV, Poveshchenko, AF, Efremova, OA, Mironov, YV & Shestopalov, MA 2017, 'A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity', Toxicology Research, том. 6, № 4, стр. 554-560. https://doi.org/10.1039/c7tx00083a

A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity. / Krasilnikova, Anna A.; Solovieva, Anastasiya O.; Ivanov, Anton A. и др.

В: Toxicology Research, Том 6, № 4, 01.07.2017, стр. 554-560.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

TY - JOUR

T1 - A comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes' toxicity

AU - Krasilnikova, Anna A.

AU - Solovieva, Anastasiya O.

AU - Ivanov, Anton A.

AU - Brylev, Konstantin A.

AU - Pozmogova, Tatiana N.

AU - Gulyaeva, Marina A.

AU - Kurskaya, Olga G.

AU - Alekseev, Alexander Y.

AU - Shestopalov, Alexander M.

AU - Shestopalova, Lidiya V.

AU - Poveshchenko, Alexander F.

AU - Efremova, Olga A.

AU - Mironov, Yuri V.

AU - Shestopalov, Michael A.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2017.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - The octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to the difficulty in controlling the hydrolysis of the initial P(C2H4CN)3 ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] with those of related compounds featuring the fully hydrolysed form of the phosphine ligand, namely Na2H14[{Re6Q8}(P(C2H4COO)3)6] (Q = S or Se). Our results demonstrate that the cytotoxicity and acute in vivo toxicity of the complex Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] solutions were considerably lower than those of compounds with the fully hydrolysed ligand P(C2H4COOH)3. Such behavior can be explained by the higher osmolality of Na2H14[{Re6Q8}(P(C2H4COO)3)6] versus Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6].

AB - The octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to the difficulty in controlling the hydrolysis of the initial P(C2H4CN)3 ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] with those of related compounds featuring the fully hydrolysed form of the phosphine ligand, namely Na2H14[{Re6Q8}(P(C2H4COO)3)6] (Q = S or Se). Our results demonstrate that the cytotoxicity and acute in vivo toxicity of the complex Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] solutions were considerably lower than those of compounds with the fully hydrolysed ligand P(C2H4COOH)3. Such behavior can be explained by the higher osmolality of Na2H14[{Re6Q8}(P(C2H4COO)3)6] versus Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6].

KW - CELLS

KW - CELLULAR INTERNALIZATION

KW - CHRONIC INFLAMMATION

KW - CYTOTOXICITY

KW - DISEASES

KW - ENCAPSULATION

KW - GOLD NANOPARTICLES

KW - LUMINESCENCE

KW - RAY CONTRAST AGENT

KW - SILICA NANOPARTICLES

UR - http://www.scopus.com/inward/record.url?scp=85021715820&partnerID=8YFLogxK

U2 - 10.1039/c7tx00083a

DO - 10.1039/c7tx00083a

M3 - Article

C2 - 30090524

AN - SCOPUS:85021715820

VL - 6

SP - 554

EP - 560

JO - Toxicology Research

JF - Toxicology Research

SN - 2045-452X

IS - 4

ER -