Epigenetic Mechanisms of Blood-Pressure Regulation

A. L. Markel; O. E. Redina

doi:10.7868/S0026898418020027

Epigenetic Mechanisms of Blood-Pressure Regulation

Переведенное название: Эпигенетические механизмы в регуляции артериального давления

A. L. Markel, O. E. Redina

Результат исследования: Научные публикации в периодических изданиях › обзорная статья › рецензирование

1 Цитирования (Scopus)

Аннотация

Рассмотрена роль эпигенетических механизмов в регуляции артериального давления. Известно, что на некоторых стадиях раннего пре- и постнатального онтогенеза организм особенно чувствителен к воздействию средовых и эндогенных факторов. Именно в эти периоды происходит формирование комплекса эпигенетических изменений, которые определяют траекторию дальнейшего развития физиологических систем, регулирующих артериальное давление. Состояние этих систем может определять вероятность формирования гипертонической болезни. Трансгенерационная передача эпигенетических меток в некоторых случаях позволяет разрешить противоречие между высокой наследуемостью гипертонической болезни и малым суммарным вкладом полиморфных вариантов ДНК в популяци-онную вариабельность величин артериального давления

Переведенное название	Эпигенетические механизмы в регуляции артериального давления
Язык оригинала	английский
Страницы (с-по)	172-189
Число страниц	18
Журнал	Molekuliarnaia biologiia
Том	52
Номер выпуска	2
DOI	https://doi.org/10.7868/S0026898418020027
Состояние	Опубликовано - 27 апр 2018

Ключевые слова

Animals
Blood Pressure
Epigenesis, Genetic
Genetic Predisposition to Disease
Humans
Hypertension/genetics

ГРНТИ

34 БИОЛОГИЯ

Доступ к документу

10.7868/S0026898418020027

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abstract = "The role of epigenetic mechanisms involved in blood-pressure regulation has been reviewed. It is known that some periods in early pre- and postnatal ontogenesis are very sensitive to some environmental and endogenous influences. These periods are characterized as highly vulnerable to the formation of a complex of epigenetic changes that may determine the trajectory of the further formation of physiological systems involved in the blood-pressure regulation. Early life influences on these systems may predispose an individual to the development of hypertensive disease in further life. In some cases, the transmission of epigenetic changes to the next generations may resolve the contradiction between the high heritability of arterial hypertensive disease and the low total contribution of polymorphic DNA variants in the population variability of blood pressure values.",

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AB - The role of epigenetic mechanisms involved in blood-pressure regulation has been reviewed. It is known that some periods in early pre- and postnatal ontogenesis are very sensitive to some environmental and endogenous influences. These periods are characterized as highly vulnerable to the formation of a complex of epigenetic changes that may determine the trajectory of the further formation of physiological systems involved in the blood-pressure regulation. Early life influences on these systems may predispose an individual to the development of hypertensive disease in further life. In some cases, the transmission of epigenetic changes to the next generations may resolve the contradiction between the high heritability of arterial hypertensive disease and the low total contribution of polymorphic DNA variants in the population variability of blood pressure values.

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KW - Epigenesis, Genetic

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