Epigenetic Mechanisms of Blood-Pressure Regulation

A. L. Markel; O. E. Redina

doi:10.7868/S0026898418020027

Epigenetic Mechanisms of Blood-Pressure Regulation

Переведенное название: Эпигенетические механизмы в регуляции артериального давления

A. L. Markel, O. E. Redina

Результат исследования: Научные публикации в периодических изданиях › обзорная статья › рецензирование

1 Цитирования (Scopus)

Аннотация

Рассмотрена роль эпигенетических механизмов в регуляции артериального давления. Известно, что на некоторых стадиях раннего пре- и постнатального онтогенеза организм особенно чувствителен к воздействию средовых и эндогенных факторов. Именно в эти периоды происходит формирование комплекса эпигенетических изменений, которые определяют траекторию дальнейшего развития физиологических систем, регулирующих артериальное давление. Состояние этих систем может определять вероятность формирования гипертонической болезни. Трансгенерационная передача эпигенетических меток в некоторых случаях позволяет разрешить противоречие между высокой наследуемостью гипертонической болезни и малым суммарным вкладом полиморфных вариантов ДНК в популяци-онную вариабельность величин артериального давления

Переведенное название	Эпигенетические механизмы в регуляции артериального давления
Язык оригинала	английский
Страницы (с-по)	172-189
Число страниц	18
Журнал	Molekuliarnaia biologiia
Том	52
Номер выпуска	2
DOI	https://doi.org/10.7868/S0026898418020027
Состояние	Опубликовано - 27 апр 2018

Ключевые слова

Animals
Blood Pressure
Epigenesis, Genetic
Genetic Predisposition to Disease
Humans
Hypertension/genetics

ГРНТИ

34 БИОЛОГИЯ

Доступ к документу

10.7868/S0026898418020027

Другие файлы и ссылки

Fingerprint

Подробные сведения о темах исследования «Эпигенетические механизмы в регуляции артериального давления». Вместе они формируют уникальный семантический отпечаток (fingerprint).

Цитировать

@article{8e2a606343b244ec864e25a5b7d761bb,

title = "Epigenetic Mechanisms of Blood-Pressure Regulation",

abstract = "The role of epigenetic mechanisms involved in blood-pressure regulation has been reviewed. It is known that some periods in early pre- and postnatal ontogenesis are very sensitive to some environmental and endogenous influences. These periods are characterized as highly vulnerable to the formation of a complex of epigenetic changes that may determine the trajectory of the further formation of physiological systems involved in the blood-pressure regulation. Early life influences on these systems may predispose an individual to the development of hypertensive disease in further life. In some cases, the transmission of epigenetic changes to the next generations may resolve the contradiction between the high heritability of arterial hypertensive disease and the low total contribution of polymorphic DNA variants in the population variability of blood pressure values.",

keywords = "blood pressure, epigenetic mechanisms, hypertension, Animals, Blood Pressure, Epigenesis, Genetic, Genetic Predisposition to Disease, Humans, Hypertension/genetics",

author = "Markel, {A. L.} and Redina, {O. E.}",

year = "2018",

month = apr,

day = "27",

doi = "10.7868/S0026898418020027",

language = "English",

volume = "52",

pages = "172--189",

journal = "Molekulyarnaya Biologiya",

issn = "0026-8984",

publisher = "Russian Academy of Sciences",

number = "2",

}

TY - JOUR

T1 - Epigenetic Mechanisms of Blood-Pressure Regulation

AU - Markel, A. L.

AU - Redina, O. E.

PY - 2018/4/27

Y1 - 2018/4/27

N2 - The role of epigenetic mechanisms involved in blood-pressure regulation has been reviewed. It is known that some periods in early pre- and postnatal ontogenesis are very sensitive to some environmental and endogenous influences. These periods are characterized as highly vulnerable to the formation of a complex of epigenetic changes that may determine the trajectory of the further formation of physiological systems involved in the blood-pressure regulation. Early life influences on these systems may predispose an individual to the development of hypertensive disease in further life. In some cases, the transmission of epigenetic changes to the next generations may resolve the contradiction between the high heritability of arterial hypertensive disease and the low total contribution of polymorphic DNA variants in the population variability of blood pressure values.

AB - The role of epigenetic mechanisms involved in blood-pressure regulation has been reviewed. It is known that some periods in early pre- and postnatal ontogenesis are very sensitive to some environmental and endogenous influences. These periods are characterized as highly vulnerable to the formation of a complex of epigenetic changes that may determine the trajectory of the further formation of physiological systems involved in the blood-pressure regulation. Early life influences on these systems may predispose an individual to the development of hypertensive disease in further life. In some cases, the transmission of epigenetic changes to the next generations may resolve the contradiction between the high heritability of arterial hypertensive disease and the low total contribution of polymorphic DNA variants in the population variability of blood pressure values.

KW - blood pressure

KW - epigenetic mechanisms

KW - hypertension

KW - Animals

KW - Blood Pressure

KW - Epigenesis, Genetic

KW - Genetic Predisposition to Disease

KW - Humans

KW - Hypertension/genetics

UR - http://www.scopus.com/inward/record.url?scp=85055079228&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=32619491

U2 - 10.7868/S0026898418020027

DO - 10.7868/S0026898418020027

M3 - Review article

C2 - 29695687

AN - SCOPUS:85055079228

VL - 52

SP - 172

EP - 189

JO - Molekulyarnaya Biologiya

JF - Molekulyarnaya Biologiya

SN - 0026-8984

IS - 2

ER -