In vitro photodynamic inactivation of Mycobacterium tuberculosis by methylene blue

D. Bredikhin; S. D. Nikonov; A. G. Cherednichenko; T. I. Petrenko; A. I. Korbut

doi:10.21292/2075-1230-2019-97-7-28-33

In vitro photodynamic inactivation of Mycobacterium tuberculosis by methylene blue

Переведенное название: Фотодинамическая инактивация Mycobacterium tuberculosis метиленовым синим in vitro

D. Bredikhin, S. D. Nikonov, A. G. Cherednichenko, T. I. Petrenko, A. I. Korbut

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

2 Цитирования (Scopus)

Аннотация

Цель: исследование противотуберкулезных эффектов лазерной фотодинамической инактивации (ФДИ) M. tuberculosis H37Rv in vitro метиленовым синим (МС) в минимальной концентрации (1 мкг/мл) при лазерном излучении длиной волны 662 нм. Материалы и методы. Проведен сравнительный анализ интенсивности роста Mycobacterium tuberculosis H37Rv после лазерного облучения и лазерной ФДИ МС при различных дозах световой энергии. Результаты. Обнаружено, что лазерное излучение длиной волны 662 нм оказывает ингибирующее действие на ростовые свойства M. tuberculosis H37Rv. Впервые зарегистрирована ФДИ микобактерий туберкулеза в присутствии минимальной концентрации МС (1 мкг/мл), при которой реализуется подавление роста колоний на 97 и 93% при их обработке излучением длиной волны 662 нм с наименьшими значениями плотности доз световой энергии (46,9 и 93,75 Дж/см2)

Переведенное название	Фотодинамическая инактивация Mycobacterium tuberculosis метиленовым синим in vitro
Язык оригинала	английский
Страницы (с-по)	28-33
Число страниц	6
Журнал	Tuberculosis and Lung Diseases
Том	97
Номер выпуска	7
DOI	https://doi.org/10.21292/2075-1230-2019-97-7-28-33
Состояние	Опубликовано - 1 янв 2019

Ключевые слова

Anti-microbial photodynamic therapy
Methylene blue
Mycobacterium tuberculosis HRv
Tuberculosis

ГРНТИ

76 МЕДИЦИНА И ЗДРАВООХРАНЕНИЕ

Доступ к документу

10.21292/2075-1230-2019-97-7-28-33

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@article{62181d678d0b44b7aff0100d793abb26,

title = "In vitro photodynamic inactivation of Mycobacterium tuberculosis by methylene blue",

abstract = "The objective: to investigate the anti-tuberculosis effect of laser photodynamic inactivation (PDI) of M. tuberculosis H37Rv in vitro by methylene blue (MB) in the minimum concentration (1 μg/ml) with laser radiation of 662 nm. Subjects and methods. A comparative analysis of the intensity of growth of Mycobacterium tuberculosis H37Rv after laser irradiation and laser FDI by MB with different doses of light energy was carried out. Results. Laser radiation with a wavelength of 662 nm was found to have an inhibitory effect on the growth of M. tuberculosis H37Rv. FDI of Mycobacterium tuberculosis was first registered in the presence of a minimum concentration of MB (1 µg/ml) which suppressed colony growth by 97 and 93% when they were processed by radiation with a wavelength of 662 nm with the lowest density of doses of light energy (46.9 and 93.75 J/cm2).",

keywords = "Anti-microbial photodynamic therapy, Methylene blue, Mycobacterium tuberculosis HRv, Tuberculosis",

author = "D. Bredikhin and Nikonov, {S. D.} and Cherednichenko, {A. G.} and Petrenko, {T. I.} and Korbut, {A. I.}",

note = "Бредихин Д.А., Никонов С.Д., Чередниченко А.Г., Петренко Т.И., Корбут А.И. Фотодинамическая инактивация Mycobacterium tuberculosis метиленовым синим in vitro // Туберкулез и болезни легких. - 2019. - Т. 97. - № 7. - С. 28-33",

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doi = "10.21292/2075-1230-2019-97-7-28-33",

language = "English",

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journal = "Tuberculosis and Lung Diseases",

issn = "2075-1230",

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In vitro photodynamic inactivation of Mycobacterium tuberculosis by methylene blue. / Bredikhin, D.; Nikonov, S. D.; Cherednichenko, A. G.; Petrenko, T. I.; Korbut, A. I.

В: Tuberculosis and Lung Diseases, Том 97, № 7, 01.01.2019, стр. 28-33.

Результат исследования: Научные публикации в периодических изданиях › статья › рецензирование

TY - JOUR

T1 - In vitro photodynamic inactivation of Mycobacterium tuberculosis by methylene blue

AU - Bredikhin, D.

AU - Nikonov, S. D.

AU - Cherednichenko, A. G.

AU - Petrenko, T. I.

AU - Korbut, A. I.

N1 - Бредихин Д.А., Никонов С.Д., Чередниченко А.Г., Петренко Т.И., Корбут А.И. Фотодинамическая инактивация Mycobacterium tuberculosis метиленовым синим in vitro // Туберкулез и болезни легких. - 2019. - Т. 97. - № 7. - С. 28-33

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The objective: to investigate the anti-tuberculosis effect of laser photodynamic inactivation (PDI) of M. tuberculosis H37Rv in vitro by methylene blue (MB) in the minimum concentration (1 μg/ml) with laser radiation of 662 nm. Subjects and methods. A comparative analysis of the intensity of growth of Mycobacterium tuberculosis H37Rv after laser irradiation and laser FDI by MB with different doses of light energy was carried out. Results. Laser radiation with a wavelength of 662 nm was found to have an inhibitory effect on the growth of M. tuberculosis H37Rv. FDI of Mycobacterium tuberculosis was first registered in the presence of a minimum concentration of MB (1 µg/ml) which suppressed colony growth by 97 and 93% when they were processed by radiation with a wavelength of 662 nm with the lowest density of doses of light energy (46.9 and 93.75 J/cm2).

AB - The objective: to investigate the anti-tuberculosis effect of laser photodynamic inactivation (PDI) of M. tuberculosis H37Rv in vitro by methylene blue (MB) in the minimum concentration (1 μg/ml) with laser radiation of 662 nm. Subjects and methods. A comparative analysis of the intensity of growth of Mycobacterium tuberculosis H37Rv after laser irradiation and laser FDI by MB with different doses of light energy was carried out. Results. Laser radiation with a wavelength of 662 nm was found to have an inhibitory effect on the growth of M. tuberculosis H37Rv. FDI of Mycobacterium tuberculosis was first registered in the presence of a minimum concentration of MB (1 µg/ml) which suppressed colony growth by 97 and 93% when they were processed by radiation with a wavelength of 662 nm with the lowest density of doses of light energy (46.9 and 93.75 J/cm2).

KW - Anti-microbial photodynamic therapy

KW - Methylene blue

KW - Mycobacterium tuberculosis HRv

KW - Tuberculosis

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