Zebrafish models relevant to studying central opioid and endocannabinoid systems

Konstantin A. Demin, Darya A. Meshalkina, Elana V. Kysil, Kristina A. Antonova, Andrey D. Volgin, Oleg A. Yakovlev, Polina A. Alekseeva, Maria M. Firuleva, Anton M. Lakstygal, Murilo S. de Abreu, Leonardo J.G. Barcellos, Wandong Bao, Ashton J. Friend, Tamara G. Amstislavskaya, Denis B. Rosemberg, Pavel E. Musienko, Cai Song, Allan V. Kalueff

    Research output: Contribution to journalReview articlepeer-review

    27 Citations (Scopus)

    Abstract

    The endocannabinoid and opioid systems are two interplaying neurotransmitter systems that modulate drug abuse, anxiety, pain, cognition, neurogenesis and immune activity. Although they are involved in such critical functions, our understanding of endocannabinoid and opioid physiology remains limited, necessitating further studies, novel models and new model organisms in this field. Zebrafish (Danio rerio) is rapidly emerging as one of the most effective translational models in neuroscience and biological psychiatry. Due to their high physiological and genetic homology to humans, zebrafish may be effectively used to study the endocannabinoid and opioid systems. Here, we discuss current models used to target the endocannabinoid and opioid systems in zebrafish, and their potential use in future translational research and high-throughput drug screening. Emphasizing the high degree of conservation of the endocannabinoid and opioid systems in zebrafish and mammals, we suggest zebrafish as an excellent model organism to study these systems and to search for the new drugs and therapies targeting their evolutionarily conserved mechanisms.

    Original languageEnglish
    Pages (from-to)301-312
    Number of pages12
    JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
    Volume86
    DOIs
    Publication statusPublished - 30 Aug 2018

    Keywords

    • Endocannabinoid system
    • High-throughput screening
    • Opioid system
    • Zebrafish
    • HYDROLASE INHIBITOR URB597
    • CONDITIONED PLACE PREFERENCE
    • ADULT ZEBRAFISH
    • ANXIETY-LIKE BEHAVIOR
    • RAT MODEL
    • PHYLOGENETIC DISTRIBUTION
    • CANNABINOID CB1 RECEPTOR
    • BINDING-SITES
    • SALVINORIN-A
    • MOLECULAR-MECHANISMS
    • Zebrafish/metabolism
    • Central Nervous System/drug effects
    • Receptors, Opioid/metabolism
    • Animals
    • Models, Animal
    • Endocannabinoids/metabolism

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