Water-soluble Re 6 -clusters with aromatic phosphine ligands-from synthesis to potential biomedical applications

Anton A. Ivanov, Dmitry I. Konovalov, Tatiana N. Pozmogova, Anastasiya O. Solovieva, Anatoly R. Melnikov, Konstantin A. Brylev, Natalia V. Kuratieva, Vadim V. Yanshole, Kaplan Kirakci, Kamil Lang, Svetlana N. Cheltygmasheva, Noboru Kitamura, Lidiya V. Shestopalova, Yuri V. Mironov, Michael A. Shestopalov

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The development of water-soluble hexanuclear cluster complexes of low toxicity is a promising task due to their potential biomedical applications such as bioimaging and photodynamic therapy. Herein, we present the syntheses of two new water-soluble hexarhenium cluster complexes with terminal amphiphilic phosphine ligands, and delineate their photoluminescence and X-ray excited optical luminescence (XEOL) properties. These cluster complexes, namely [{Re 6 Q 8 }(PPh 2 CH 2 CH 2 COO) 6 ] 4- (Q = S (1); Se, (2)), have the least cytotoxicity among all the tested hexanuclear metal-clusters, are capable of penetrating into cells and exhibit moderate photodynamic toxicity toward Hep-2 cells.

Original languageEnglish
Pages (from-to)882-892
Number of pages11
JournalInorganic Chemistry Frontiers
Volume6
Issue number4
DOIs
Publication statusPublished - 1 Apr 2019

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