Unilateral stimulation of the lateral division of the dorsal telencephalon induces synaptic plasticity in the bilateral medial division of zebrafish

Yao Ju Wu, Yu Lan Chen, Tso Hao Tang, Ming Chong Ng, Tamara G. Amstislavskaya, Maria A. Tikhonova, Yi Ling Yang, Kwok Tung Lu

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    3 Citations (Scopus)

    Abstract

    This study was aimed to evaluate the synaptic plasticity in projections from the dorsal lateral region (Dl) to the bilateral dorsal medial region (Dm) of the zebrafish telencephalon. The results showed that unilateral electrical stimulation of the Dl evokes a negative field potential (FP) in both the contralateral and ipsilateral side of the Dm. We tested synaptic plasticity, including high-frequency stimulation-induced LTP (HFS-LTP) and low-frequency stimulation-induced LTD (LFS-LTD). We demonstrated that HFS-induced bilateral LTP is NMDAR-dependent by the application of an NMDAR antagonist, DL-AP5 (30 μM, suprafused for 10 min), which blocked the HFS-induced LTP in both the contralateral and ipsilateral Dm. In addition, LTP was restored after DL-AP5 was washed out by continuous aCSF suprafusion. These results suggested that the potentiation is NMDAR-dependent. Either LFS (1 Hz for 20 min) or applying the mGluR agonist, DHPG (40 μM, suprafused for 10 min) successfully induced bilateral LTD for at least 1 h. Furthermore, both the contralateral fEPSP and LTP vanished after ablation of the anterior commissure. In conclusion, the results of the present study suggested that the projection between the Dl and contralateral Dm in the telencephalon of zebrafish is via the anterior commissure and possesses synaptic plasticity.

    Original languageEnglish
    Article number9096
    Pages (from-to)9096
    Number of pages8
    JournalScientific Reports
    Volume7
    Issue number1
    DOIs
    Publication statusPublished - 22 Aug 2017

    Keywords

    • Animals
    • Electric Stimulation/methods
    • Evoked Potentials
    • Long-Term Potentiation
    • Male
    • Methoxyhydroxyphenylglycol/analogs & derivatives
    • Neuronal Plasticity
    • Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors
    • Telencephalon/physiology
    • Zebrafish/physiology
    • NMDA RECEPTORS
    • CONNECTIONS
    • AREA CA1
    • HIPPOCAMPUS
    • MEMORY
    • CA1 REGION
    • GOLDFISH
    • IN-VIVO
    • LONG-TERM POTENTIATION
    • DHPG-INDUCED LTD

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