Understanding neurobehavioral genetics of zebrafish

Sergey V. Cheresiz, Andrey D. Volgin, Alexandra Kokorina Evsyukova, Alim A.O. Bashirzade, Konstantin A. Demin, Murilo S. de Abreu, Tamara G. Amstislavskaya, Allan V. Kalueff

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

Due to its fully sequenced genome, high genetic homology to humans, external fertilization, fast development, transparency of embryos, low cost and active reproduction, the zebrafish (Danio rerio) has become a novel promising model organism in biomedicine. Zebrafish are a useful tool in genetic and neuroscience research, including linking various genetic mutations to brain mechanisms using forward and reverse genetics. These approaches have produced novel models of rare genetic CNS disorders and common brain illnesses, such as addiction, aggression, anxiety and depression. Genetically modified zebrafish also foster neuroanatomical studies, manipulating neural circuits and linking them to different behaviors. Here, we discuss recent advances in neurogenetics of zebrafish, and evaluate their unique strengths, inherent limitations and the rapidly growing potential for elucidating the conserved roles of genes in neuropsychiatric disorders.

Original languageEnglish
Pages (from-to)203-215
Number of pages13
JournalJournal of Neurogenetics
Volume34
Issue number2
DOIs
Publication statusPublished - 2 Apr 2020

Keywords

  • brain disorders
  • forward genetics
  • reverse genetics
  • transgenic methods
  • Zebrafish
  • DANIO-RERIO
  • TRANSGENIC ZEBRAFISH
  • NEURONAL-ACTIVITY
  • KNOCK-IN
  • DOUBLE-STRANDED-RNA
  • MICRORNA PATHWAY
  • MARIE-TOOTH DISEASE
  • ANIMAL-MODELS
  • HOMOLOGOUS RECOMBINATION
  • CYCLIN-DEPENDENT KINASE-5

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