Ultrasensitive detection of inhaled organic aerosol particles by accelerator mass spectrometry

E. V. Parkhomchuk, D. G. Gulevich, A. I. Taratayko, A. M. Baklanov, A. V. Selivanova, T. A. Trubitsyna, I. V. Voronova, P. N. Kalinkin, A. G. Okunev, S. A. Rastigeev, V. A. Reznikov, V. S. Semeykina, K. A. Sashkina, V. V. Parkhomchuk

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Accelerator mass spectrometry (AMS) was shown to be applicable for studying the penetration of organic aerosols, inhaled by laboratory mice at ultra-low concentration ca. 103 cm-3. We synthesized polystyrene (PS) beads, composed of radiocarbon-labeled styrene, for testing them as model organic aerosols. As a source of radiocarbon we used methyl alcohol with radioactivity. Radiolabeled polystyrene beads were obtained by emulsifier-free emulsion polymerization of synthesized 14C-styrene initiated by K2S2O8 in aqueous media. Aerosol particles were produced by pneumatic spraying of diluted 14C-PS latex. Mice inhaled 14C-PS aerosol consisting of the mix of 103 225-nm particles per 1 cm3 and 5·103 25-nm particles per 1 cm3 for 30 min every day during five days. Several millions of 225-nm particles deposited in the lungs and slowly excreted from them during two weeks of postexposure. Penetration of particles matter was also observed for liver, kidneys and brain, but not for a heart.

Original languageEnglish
Pages (from-to)80-88
Number of pages9
JournalChemosphere
Volume159
DOIs
Publication statusPublished - 1 Sep 2016

Keywords

  • Accelerator mass-spectrometry
  • Low-dose inhalation
  • Mice
  • Organic aerosols
  • Polystyrene beads
  • Radiocarbon

Fingerprint

Dive into the research topics of 'Ultrasensitive detection of inhaled organic aerosol particles by accelerator mass spectrometry'. Together they form a unique fingerprint.

Cite this