Abstract

Experimental results of the second series of experiments on the penetration of monodisperse polymeric particles, inhaled at low dose by mice, to different organs using direct way of particle registration, based on the ultra-sensitive accelerator mass spectrometer (AMS), are presented. Polystyrene (PS) beads, composed of radiocarbon-labeled styrene, were produced for testing them as model organic aerosols. Mice inhaled 14C-PS aerosol of 3·105 ultrafine particles per 1 cm3 for 30 minutes every day during 5 days. Long-term investigation showed that PS ultrafine particles have been effectively accumulated in lungs with the maximum content in the fifth day of postexposure, and have also appeared in liver on the fifth day of exposure and in the brain on the 30th day of experiments. No particles have been detected in kidneys, spleen, and excrements. Thirty-five millions of particles remained in the lungs after half a year of postexposure showing extremely slow removal of such particles from the organ.

Original languageEnglish
Pages (from-to)785-793
Number of pages9
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume62
Issue number11
DOIs
Publication statusPublished - 1 Sep 2019

Keywords

  • accelerator mass spectrometry
  • low-dose inhalation
  • mice
  • organic aerosols
  • polystyrene beads
  • radiocarbon
  • PULMONARY
  • TRANSLOCATION
  • MASS-SPECTROMETER
  • CIRCULATION
  • OUTDOOR
  • SIZE
  • NANOPARTICLES
  • PARTICULATE AIR-POLLUTION
  • FINE PARTICLES
  • DAILY MORTALITY

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