Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate

Svetlana A. Myz; Tatyana P. Shakhtshneider; Mikhail A. Mikhailenko; Andrey G. Ogienko; Ekaterina G. Bogdanova; Anna A. Ogienko; Svetlana A. Kuznetsova; Elena V. Boldyreva; Vladimir V. Boldyrev

doi:10.1177/1934578x1501000806

Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate

Svetlana A. Myz, Tatyana P. Shakhtshneider, Mikhail A. Mikhailenko, Andrey G. Ogienko, Ekaterina G. Bogdanova, Anna A. Ogienko, Svetlana A. Kuznetsova, Elena V. Boldyreva, Vladimir V. Boldyrev

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The purpose of this research was to develop new methods of increasing dissolution rate and solubility of betulin extracted from birch bark. The ultrafine formulation of betulin with polyethylene glycol and β-glycine was obtained by freeze-drying. The rate of release of betulin from the formulation into water was significantly higher in comparison with the initial betulin sample and its composite with polyethylene glycol obtained by ball-milling.

Original language	English
Pages (from-to)	1345-1347
Number of pages	3
Journal	Natural Product Communications
Volume	10
Issue number	8
DOIs	https://doi.org/10.1177/1934578x1501000806
Publication status	Published - 2015

Keywords

Ball-milling
Betulin
Freeze-drying
Glycine
Polyethylene glycol
Solubilization

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10.1177/1934578x1501000806

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Myz, Svetlana A. ; Shakhtshneider, Tatyana P. ; Mikhailenko, Mikhail A. ; Ogienko, Andrey G. ; Bogdanova, Ekaterina G. ; Ogienko, Anna A. ; Kuznetsova, Svetlana A. ; Boldyreva, Elena V. ; Boldyrev, Vladimir V. / Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate. In: Natural Product Communications. 2015 ; Vol. 10, No. 8. pp. 1345-1347.

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title = "Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate",

abstract = "The purpose of this research was to develop new methods of increasing dissolution rate and solubility of betulin extracted from birch bark. The ultrafine formulation of betulin with polyethylene glycol and β-glycine was obtained by freeze-drying. The rate of release of betulin from the formulation into water was significantly higher in comparison with the initial betulin sample and its composite with polyethylene glycol obtained by ball-milling.",

keywords = "Ball-milling, Betulin, Freeze-drying, Glycine, Polyethylene glycol, Solubilization",

author = "Myz, {Svetlana A.} and Shakhtshneider, {Tatyana P.} and Mikhailenko, {Mikhail A.} and Ogienko, {Andrey G.} and Bogdanova, {Ekaterina G.} and Ogienko, {Anna A.} and Kuznetsova, {Svetlana A.} and Boldyreva, {Elena V.} and Boldyrev, {Vladimir V.}",

year = "2015",

doi = "10.1177/1934578x1501000806",

language = "English",

volume = "10",

pages = "1345--1347",

journal = "Natural Product Communications",

issn = "1934-578X",

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Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate. / Myz, Svetlana A.; Shakhtshneider, Tatyana P.; Mikhailenko, Mikhail A.; Ogienko, Andrey G.; Bogdanova, Ekaterina G.; Ogienko, Anna A.; Kuznetsova, Svetlana A.; Boldyreva, Elena V.; Boldyrev, Vladimir V.

In: Natural Product Communications, Vol. 10, No. 8, 2015, p. 1345-1347.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate

AU - Myz, Svetlana A.

AU - Shakhtshneider, Tatyana P.

AU - Mikhailenko, Mikhail A.

AU - Ogienko, Andrey G.

AU - Bogdanova, Ekaterina G.

AU - Ogienko, Anna A.

AU - Kuznetsova, Svetlana A.

AU - Boldyreva, Elena V.

AU - Boldyrev, Vladimir V.

PY - 2015

Y1 - 2015

N2 - The purpose of this research was to develop new methods of increasing dissolution rate and solubility of betulin extracted from birch bark. The ultrafine formulation of betulin with polyethylene glycol and β-glycine was obtained by freeze-drying. The rate of release of betulin from the formulation into water was significantly higher in comparison with the initial betulin sample and its composite with polyethylene glycol obtained by ball-milling.

AB - The purpose of this research was to develop new methods of increasing dissolution rate and solubility of betulin extracted from birch bark. The ultrafine formulation of betulin with polyethylene glycol and β-glycine was obtained by freeze-drying. The rate of release of betulin from the formulation into water was significantly higher in comparison with the initial betulin sample and its composite with polyethylene glycol obtained by ball-milling.

KW - Ball-milling

KW - Betulin

KW - Freeze-drying

KW - Glycine

KW - Polyethylene glycol

KW - Solubilization

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DO - 10.1177/1934578x1501000806

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EP - 1347

JO - Natural Product Communications

JF - Natural Product Communications

SN - 1934-578X

IS - 8

ER -

Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate

Abstract

Keywords

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