Ultrafine betulin formulation with biocompatible carriers exhibiting improved dissolution rate

Svetlana A. Myz, Tatyana P. Shakhtshneider, Mikhail A. Mikhailenko, Andrey G. Ogienko, Ekaterina G. Bogdanova, Anna A. Ogienko, Svetlana A. Kuznetsova, Elena V. Boldyreva, Vladimir V. Boldyrev

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The purpose of this research was to develop new methods of increasing dissolution rate and solubility of betulin extracted from birch bark. The ultrafine formulation of betulin with polyethylene glycol and β-glycine was obtained by freeze-drying. The rate of release of betulin from the formulation into water was significantly higher in comparison with the initial betulin sample and its composite with polyethylene glycol obtained by ball-milling.

Original languageEnglish
Pages (from-to)1345-1347
Number of pages3
JournalNatural Product Communications
Volume10
Issue number8
DOIs
Publication statusPublished - 2015

Keywords

  • Ball-milling
  • Betulin
  • Freeze-drying
  • Glycine
  • Polyethylene glycol
  • Solubilization

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