Abstract

Three novel ruthenium nitrosyl complexes [Ru(NO)Cl3(InicMe)2] (1b), [RuNOCl3(NicEt)2] (1c) and [RuNOCl3(NicMe)2] (1d) (InicMe = methyl isonicotinate, NicEt = ethyl nicotinate, NicMe = = methyl nicotinate)were prepared and crystal structure of the complexes were determined by single crystal XRD analysis. In all complexes, the organic ligands are coordinated by a pyridine nitrogen atom and located in trans-position each to other and in cis-position to NO group. In the crystal package of all compounds stacking interactions of two types were determined: πarenearene and πCOOarene stacking. Finally, cytotoxicity of the compounds was tested on Hep2 and HepG2 cell lines. In the set of similar compounds mer-[RuNO(L)2Cl3] (L = Py, γ-Pic, β-Pic, Inic-Alk, Nic-Alk), complexes with iso-nicotinic acid esters are the most toxic, while nicotinic acid derivatives are less toxic and compared with pyridine complex.

Original languageEnglish
Article number128565
Number of pages8
JournalJournal of Molecular Structure
Volume1219
DOIs
Publication statusPublished - 5 Nov 2020

Keywords

  • Biological activity
  • Heterocycles
  • Nitrosyl complexes
  • Ruthenium
  • DRUG
  • NITRIC-OXIDE
  • CRYSTAL
  • NO-RELEASE
  • BIOLOGICAL-PROPERTIES
  • CANCER

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