Translocation of Oligonucleotide–Oligosaccharide Complexes into Cells of the Brain

N. N. Dygalo, T. S. Kalinina, D. A. Lanshakov

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Irradiation of a mixture of oligonucleotides with dextran resulted in the formation of a complex that is detected by a decelerated migration of an irradiated sample in electrophoretic gel compared to a non-irradiated one. When injected into the brain of neonatal rats, the formed complex penetrated into the cells 3 times easier compared to the original oligonucleotide, thus indicating that the use of radiation crosslinking of oligonucleotides with oligosaccharides is promising to enhance the efficiency of delivery of gene-targeted oligonucleotide drugs into cells.

Original languageEnglish
Pages (from-to)108-110
Number of pages3
JournalDoklady Biochemistry and Biophysics
Volume479
Issue number1
DOIs
Publication statusPublished - 1 Mar 2018

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