@article{e91c5cc7ac6e49e4a7d79891a01c3845,
title = "Towards Modeling Anhedonia and Its Treatment in Zebrafish",
abstract = "Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and extensively validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders, including depression. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications.",
keywords = "Anhedonia, animal models, antidepressant, behavior, zebrafish, CONDITIONED PLACE PREFERENCE, STRESS-INDUCED ANHEDONIA, MAJOR DEPRESSIVE DISORDER, NUCLEUS-ACCUMBENS DOPAMINE, ANIMAL-MODEL, SOCIAL-INTERACTION, ADULT ZEBRAFISH, DANIO-RERIO, BIOLOGICAL MECHANISMS, RECOGNITION MEMORY, Antidepressive Agents/pharmacology, Zebrafish, Behavior, Animal, Animals, Disease Models, Animal",
author = "{de Abreu}, {Murilo S.} and Fabiano Costa and Giacomini, {Ana C. V. V.} and Demin, {Konstantin A.} and Zabegalov, {Konstantin N.} and Maslov, {Gleb O.} and Kositsyn, {Yuriy M.} and Elena Petersen and Tatiana Strekalova and Rosemberg, {Denis B.} and Allan Kalueff",
note = "The study is supported by the Southwest University Zebrafish Platform Construction Funds (Chongqing, China). A.V.K. is the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) that coordinated this collaborative project. D.B.R.'s research is also supported by Programa de Excelencia Academica (PROEX)/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) (process no. 23038.005450/2020-19) and Program PQ-{"}Gaucho{"} Fundacao de Amparo a Pesquisa do Rio Grande do Sul (FAPERGS) (process no. 19/2551-0001764-2) fellowship grants. A.C.V.V.G. is supported by the FAPERGS research fellowships 19/2551-0001-669-7. A.V.K. is supported by the Zebrafish Platform Construction Fund from the Southwest University (Chongqing, China). K.A.D. is supported by the Special Rector's Fellowship for SPSU students, and state budgetary funds to Granov Russian Scientific Research Center of Radiology and Surgical Technologies (project 121040200141-4). The collaboration was supported by the Russian Science Foundation grant 20-65-46006. The work used the equipment of the Resource Fund of Applied Genetics MIPT (support grant 075-15-2021-684). K.N.Z., F.C. and G.O.M. are supported by Sirius University of Science and Technology. The funders had no role in the design, analyses and interpretation of the submitted study, or decision to publish.",
year = "2022",
month = apr,
day = "1",
doi = "10.1093/ijnp/pyab092",
language = "English",
volume = "25",
pages = "293--306",
journal = "International journal of neuropsychopharmacology",
issn = "1461-1457",
publisher = "OXFORD UNIV PRESS INC",
number = "4",
}