Three-dimensional simulation of the Caenorhabditis elegans body and muscle cells in liquid and gel environments for behavioural analysis

Andrey Palyanov, Sergey Khayrulin, Stephen D. Larson

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

To better understand how a nervous system controls the movements of an organism, we have created a three-dimensional computational biomechanical model of the Caenorhabditis elegans body based on real anatomical structure. The body model is created with a particle system-based simulation engine known as Sibernetic,which implements thesmoothed particle-hydrodynamics algorithm. The model includes an elastic body-wall cuticle subject to hydrostatic pressure. This cuticle is then driven by body-wall muscle cells that contract and relax, whose positions and shape are mapped from C. Elegans anatomy, and determined from light microscopy and electron micrograph data. We show that by using different muscle activation patterns, this model is capable of producing C. Elegans-like behaviours, including crawling and swimming locomotion in environments with different viscosities, while fitting multiple additional known biomechanical properties of the animal. This article is part of a discussion meeting issue 'Connectome to behaviour: modelling C. Elegans at cellular resolution'.

Original languageEnglish
Article number20170376
Number of pages10
JournalPhilosophical Transactions of the Royal Society B: Biological Sciences
Volume373
Issue number1758
DOIs
Publication statusPublished - 10 Sep 2018

Keywords

  • Caenorhabditis elegans
  • Crawling
  • OpenWorm
  • Sibernetic
  • Simulation
  • Swimming
  • Locomotion/physiology
  • Computational Biology
  • Hydrodynamics
  • Hydrostatic Pressure
  • Biomechanical Phenomena
  • Animals
  • Models, Biological
  • Caenorhabditis elegans/physiology
  • LOW-REYNOLDS-NUMBER
  • SYSTEM
  • simulation
  • UNDULATORY LOCOMOTION
  • swimming
  • ADAPTATION
  • FORCES
  • C.-ELEGANS
  • GAIT
  • WORM
  • crawling

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