Theoretical Substantiation for the Original Technique of Photodynamic Fractional Laser Photothermolysis (PFLP) for Dermatology, based on Intradermal Transport of Photosensibilisers

Sergey Nikonov, Danila Chernopyatov, Oleg Shumkov, Mikhail Soluyanov, Mikhail Smagin

Research output: Chapter in Book/Report/Conference proceedingConference contributionResearchpeer-review

Abstract

This review demonstrates the progress, current status and problems of photodynamic therapy and laser photothermolysis for various skin diseases and rejuvenation. These new minimally invasive technologies are detailed from the points of view of their advantages and disadvantages. Particular attention is paid to complications, associated with prolonged dermal phototoxicity after intravenous photosensibilisation and insufficient intradermal penetration of photosensibilisers after local application to skin. Finding a compromise between phototoxicity and insufficiency of local photosensibilisation we've developed a technical approach employed to overcome limitations associated with targeted delivery of photosensibilisers into deep dermal layers. Intradermal delivery of photosensibilisers through so-called microthermal zones or dermal micropores, formed by focused pulse-periodic radiation of fiber laser, previously never used for photodynamic therapy of dermal disorders.

Original languageEnglish
Title of host publicationSIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1007-1010
Number of pages4
ISBN (Electronic)9781728144016
DOIs
Publication statusPublished - Oct 2019
Event2019 International Multi-Conference on Engineering, Computer and Information Sciences, SIBIRCON 2019 - Novosibirsk, Russian Federation
Duration: 21 Oct 201927 Oct 2019

Publication series

NameSIBIRCON 2019 - International Multi-Conference on Engineering, Computer and Information Sciences, Proceedings

Conference

Conference2019 International Multi-Conference on Engineering, Computer and Information Sciences, SIBIRCON 2019
CountryRussian Federation
CityNovosibirsk
Period21.10.201927.10.2019

Keywords

  • drug delivery
  • intradermal transport. skin diseases
  • photodynamic therapy
  • photothermolysis
  • rejuvenation

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