The role of phosphatidyIinositol-3-kinase in carcinogenesis

N. A. Oskina, A. M. Shcherbakov, L. K. Ovchinnikova, M. L. Filipenko, N. E. Kushlinsky

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Currently it is established that cancer is a genetic disease and that somatic mutations are the initiators of the carcinogenic process. The PI3K/AKT/mTOR pathway is an important intracellular signaling pathway regulating the cell growth and metabolic activities. Aberrant activation of the PI3K. pathway is commonly observed in many different cancers. In this review we analyze the genetic alterations of PI3K pathway in a variety of human malignancies and discuss their possible implications for diagnosis and therapy.

    Original languageEnglish
    Pages (from-to)545-556
    Number of pages12
    JournalVoprosy Onkologii
    Volume63
    Issue number4
    Publication statusPublished - 2017

    Keywords

    • 5-bisphosphate 3-kinase
    • Apoptosis
    • Carcinogenesis
    • Catalytic subunit alpha (PIK3CA)
    • Phos-phatidylinositol-4
    • Phosphatidylinositol-3-kinases (PI3K)
    • PI3K/AKT/mTOR pathway

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