The role of long non-coding RNAs in the pathogenesis of hereditary diseases

Peter Sparber, Alexandra Filatova, Mira Khantemirova, Mikhail Skoblov

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Background: Thousands of long non-coding RNA (lncRNA) genes are annotated in the human genome. Recent studies showed the key role of lncRNAs in a variety of fundamental cellular processes. Dysregulation of lncRNAs can drive tumorigenesis and they are now considered to be a promising therapeutic target in cancer. However, how lncRNAs contribute to the development of hereditary diseases in human is still mostly unknown. Results: This review is focused on hereditary diseases in the pathogenesis of which long non-coding RNAs play an important role. Conclusions: Fundamental research in the field of molecular genetics of lncRNA is necessary for a more complete understanding of their significance. Future research will help translate this knowledge into clinical practice which will not only lead to an increase in the diagnostic rate but also in the future can help with the development of etiotropic treatments for hereditary diseases.

Original languageEnglish
Article number42
Pages (from-to)42
Number of pages16
JournalBMC Medical Genomics
Volume12
Issue numberSuppl 2
DOIs
Publication statusPublished - 13 Mar 2019

Keywords

  • Gene regulation
  • Hereditary disease
  • lncRNA
  • Long non-coding RNA
  • Medical genetics
  • METHYLATION
  • PROTEIN
  • CIRCULAR RNA
  • ALZHEIMERS-DISEASE
  • SINGLE NUCLEOTIDE
  • H19
  • MRP RNA
  • GENE-EXPRESSION
  • ANTISENSE TRANSCRIPT
  • LNCRNA

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