The role of fluids in high-pressure polymorphism of drugs: Different behaviour of β-chlorpropamide in different inert gas and liquid media

B. A. Zakharov, Y. V. Seryotkin, N. A. Tumanov, D. Paliwoda, M. Hanfland, A. V. Kurnosov, E. V. Boldyreva

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The hydrostatic compression of β-chlorpropamide gives different high-pressure phases, depending on the choice of pressure-transmitting fluid (paraffin, neon and helium). This is particularly surprising as none of these fluids interact obviously with the solid at ambient pressure. This phenomenon is not related to dissolution and recrystallization, in contrast to what has been previously observed for β-chlorpropamide in a 1:1 pentane-isopentane mixture.

Original languageEnglish
Pages (from-to)92629-92637
Number of pages9
JournalRSC Advances
Volume6
Issue number95
DOIs
Publication statusPublished - 2016

Fingerprint

Dive into the research topics of 'The role of fluids in high-pressure polymorphism of drugs: Different behaviour of β-chlorpropamide in different inert gas and liquid media'. Together they form a unique fingerprint.

Cite this