Abstract

We have proposed previously a template-assisted method for 3D assembly of nucleic acid nanostructures. The method involved a branched oligonucleotide as a template and a building block, which incorporates non-nucleotidic linkers, in particular, branching foci connecting two or three oligonucleotide chains. In this work, we have attempted the synthesis of branched oligonucleotide templates for the assembly of a DNA tetrahedron and a DNA cube, a branched oligonucleotide building block (“starlet”), and studied the assembly of a DNA tetrahedron.

Original languageEnglish
Pages (from-to)700-712
Number of pages13
JournalRussian Journal of Bioorganic Chemistry
Volume47
Issue number3
DOIs
Publication statusPublished - May 2021

Keywords

  • click chemistry
  • DNA nanotechnology
  • nucleic acid
  • photolabile protecting group
  • solid-phase synthesis
  • strain-promoted azide-alkyne cycloaddition (SPAAC)

OECD FOS+WOS

  • 1.06 BIOLOGICAL SCIENCES
  • 1.04 CHEMICAL SCIENCES
  • 1.06.CQ BIOCHEMISTRY & MOLECULAR BIOLOGY

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