Synthetic Transformations of Sesquiterpene Lactones. 11.* Conjugates Based on Caffeine and Eudesmanolides with N-Containing Linkers

D. V. Reshetnikov, S. S. Patrushev, E. E. Shults

Research output: Contribution to journalArticlepeer-review

Abstract

8-(Aminoalkylamino)caffeine or 8-(piperazinyl)caffeine were formed in high yields by reacting 8-bromo- or 8-chlorocaffeine with linear and cyclic diamines using microwave-assisted organic synthesis. These amines were highly reactive in Michael reactions with sesquiterpene lactones containing active methylene groups. Conjugates with caffeine and eudesmanolide moieties bonded by a N-containing linker were synthesized.

Original languageEnglish
Pages (from-to)855-860
Number of pages6
JournalChemistry of Natural Compounds
Volume56
Issue number5
DOIs
Publication statusPublished - 1 Sep 2020

Keywords

  • caffeine
  • eudesmanolides
  • methylenelactones
  • Michael reaction

OECD FOS+WOS

  • 3.01.TU PHARMACOLOGY & PHARMACY

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