Synthesis, Structure, and Cytotoxicity of Pd(II) and Cu(II) Complexes with 1-Terpenyl-3-Thiosemicarbazides of Pinane and para-Menthane Series

T. E. Kokina, V. Yu Komarov, L. A. Glinskaya, S. N. Bizyaev, L. A. Sheludyakova, Yu A. Eremina, L. S. Klyushova, A. V. Tkachev

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Abstract

PdL1,2Cl2·H2O (I, II) and CuL1Cl2·H2O (III) complexes (L1 and L2 are 1-terpenyl-3-thiosemicarbazides of pinane and para-menthane series, respectively) are obtained. Single crystals of complexes I and [PdL3Cl2] (IV) (L3 is the product of hydrochlorination of ligand L2) have been grown. According to XRD data, crystal structures of I, IV consist of complex cations [PdLCl]+ and outer-sphere anions Cl. The coordination polyhedron N2SCl is a distorted square. L1 and L3 are tridentate ligands. Free ligands L1, L2 and complexes I-III are studied using IR spectroscopy; conclusions on the structure of the Cu(II) complex are inferred from the analysis of obtained data. Cytotoxic properties of L1, complexes I and III, as well as the carboplatin pharmaceutic are studied on the Hep2 (human larynx carcinoma) cell line. Complexes I and III are shown to be moderately cytotoxic: they are twice as less toxic with respect to Hep2 cells than carboplatin that is used in the experiment as the reference complex.

Original languageEnglish
Pages (from-to)44-56
Number of pages13
JournalJournal of Structural Chemistry
Volume61
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • complexes
  • copper
  • cytotoxicity
  • palladium
  • structure
  • terpenes
  • thiosemicarbazides
  • COPPER(I)
  • TRANSITION-METAL-COMPLEXES
  • (+)-CAMPHOR
  • COORDINATION
  • ALPHA-PINENE
  • LIGANDS
  • THIOSEMICARBAZONES
  • PALLADIUM(II)
  • NITROSO CHLORIDES
  • DERIVATIVES

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