PdL1,2Cl2·H2O (I, II) and CuL1Cl2·H2O (III) complexes (L1 and L2 are 1-terpenyl-3-thiosemicarbazides of pinane and para-menthane series, respectively) are obtained. Single crystals of complexes I and [PdL3Cl2] (IV) (L3 is the product of hydrochlorination of ligand L2) have been grown. According to XRD data, crystal structures of I, IV consist of complex cations [PdLCl]+ and outer-sphere anions Cl−. The coordination polyhedron N2SCl is a distorted square. L1 and L3 are tridentate ligands. Free ligands L1, L2 and complexes I-III are studied using IR spectroscopy; conclusions on the structure of the Cu(II) complex are inferred from the analysis of obtained data. Cytotoxic properties of L1, complexes I and III, as well as the carboplatin pharmaceutic are studied on the Hep2 (human larynx carcinoma) cell line. Complexes I and III are shown to be moderately cytotoxic: they are twice as less toxic with respect to Hep2 cells than carboplatin that is used in the experiment as the reference complex.
- NITROSO CHLORIDES