Synthesis of novel labdanoid–Based macroheterocycles using click–Cycloaddition reaction protocol

Yurii V. Kharitonov; Makhmut M. Shakirov; Elvira E. Shults

doi:10.6060/mhc160959s

Synthesis of novel labdanoid–Based macroheterocycles using click–Cycloaddition reaction protocol

Yurii V. Kharitonov, Makhmut M. Shakirov, Elvira E. Shults

Radiocarbon Methods Laboratory

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A convenient synthetic method to diterpenoid dialkyne 18-propargyloxy-16-[(prop-2-yn-1-yloxi)methyl]labda-8(17),13,15-triene in the common yield of 34% from the natural plant diterpenoid lambertianic acid was developed. 1,2,3-Triazolyl containing macroheterocyclic compounds with an integrated diterpenoid fragment have been prepared by CuAAC reaction of the labdanoid dialkyne with organic diazides.

Original language	English
Pages (from-to)	117-122
Number of pages	6
Journal	Macroheterocycles
Volume	10
Issue number	1
DOIs	https://doi.org/10.6060/mhc160959s
Publication status	Published - 1 Jan 2017

Keywords

CuAAC-reaction
Dialkynes
Diazides
Diterpenoids
Lamberianic acid
Macrocycles

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10.6060/mhc160959s

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Cite this

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title = "Synthesis of novel labdanoid–Based macroheterocycles using click–Cycloaddition reaction protocol",

abstract = "A convenient synthetic method to diterpenoid dialkyne 18-propargyloxy-16-[(prop-2-yn-1-yloxi)methyl]labda-8(17),13,15-triene in the common yield of 34% from the natural plant diterpenoid lambertianic acid was developed. 1,2,3-Triazolyl containing macroheterocyclic compounds with an integrated diterpenoid fragment have been prepared by CuAAC reaction of the labdanoid dialkyne with organic diazides.",

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