Synthesis of hybrid molecules containing pyrimidine and diterpene alkaloid lappaconitine fragments

Kirill P. Cheremnykh, Viktor Savel’ev, Oleg P. Shkurko, Elvira E. Shults

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    [Figure not available: see fulltext.] The cross coupling of 5'-ethynyllappaconitine with benzoic acid chlorides under the conditions of the Sonogashira reaction in benzene leads to the corresponding 5-alkynones. By condensation of the obtained 5'-alkynones with amidines, compounds with hybrid structure containing fragments of a diterpene alkaloid and pyrimidine were synthesized. The yields of the target compounds were 67–90%. The possibility of carrying out the cross coupling – condensation reaction as a one-pot synthesis is demonstrated.

    Original languageEnglish
    Pages (from-to)1131-1138
    Number of pages8
    JournalChemistry of Heterocyclic Compounds
    Volume54
    Issue number12
    DOIs
    Publication statusPublished - 18 Jan 2019

    Keywords

    • alkaloids
    • alkynes
    • amidines
    • cross coupling
    • one-pot synthesis
    • pyrimidines
    • DESIGN
    • ALTAI
    • FLORA
    • MODE
    • BIOLOGICAL EVALUATION
    • AGENTS
    • INHIBITORS

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