Synthesis of benzo[c][1,7]naphthyridine derivatives

Anton L. Shatsauskas, Elina R. Saibulina, Yurii V. Gatilov, Anastasia S. Kostyuchenko, Alexander S. Fisyuk

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Reactivity of 2-methyl-6-phenylbenzo[c][1,7]naphthyridine in alkylation, oxidation, and electrophilic substitution reactions has been studied. The reaction of 2-methyl-6-phenylbenzo[c][1,7]naphthyridines with POCl3 yielded the previously unknown 4-chloro-2-methyl-6-phenylbenzo[c][1,7]naphthyridine. Its dehalogenation and substitution of halogen by nitrogen and sulfur nucleophiles were studied.

Original languageEnglish
Pages (from-to)1080-1086
Number of pages7
JournalChemistry of Heterocyclic Compounds
Volume55
Issue number11
DOIs
Publication statusPublished - 1 Nov 2019

Keywords

  • alkylation
  • benzo[c][1,7]naphthyridine
  • electrophilic substitution
  • nucleophilic substitution
  • oxidation
  • reactivity
  • MARINE NATURAL-PRODUCT
  • CHEMISTRY
  • ANTAGONISTS
  • AAPTAMINE
  • ALKALOIDS

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