Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections

A. S. Sokolova, D. V. Baranova, O. I. Yarovaya, D. S. Baev, O. A. Polezhaeva, A. V. Zybkina, D. N. Shcherbakov, T. G. Tolstikova, N. F. Salakhutdinov

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

N-Heterocycle-containing (1S)-(+)-camphor-10-sulfonamide derivatives were synthesized. Their antiviral activity against the Ebola and Marburg viruses was estimated using a pseudovirus system based on the vesicular stomatitis virus. The derivatives bearing morpholine and triazole moieties demonstrated the highest inhibitory activity towards the Ebola virus glycoprotein. A moderate activity against the Marburg virus was found for a compound containing the piperidine moiety. A molecular modeling of the interaction between the synthesized derivatives and the binding site of glycoprotein of the Ebola virus was performed.

Original languageEnglish
Pages (from-to)1041-1046
Number of pages6
JournalRussian Chemical Bulletin
Volume68
Issue number5
DOIs
Publication statusPublished - 1 May 2019

Keywords

  • (1S)-(+)-camphor-10-sulfonic acid
  • Ebola virus
  • Marburg virus
  • molecular docking
  • N-heterocycles
  • pseudotyped viruses

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