1 Citation (Scopus)

Abstract

The paper describes the synthesis of new tetrahydroberberrubine derivatives containing polyfl uorophenyl- or alkylsulfonate groups at the O(9) position as well as those containing or not containing a bromine atom at the C(12) position. In a model of acute Triton-induced hyperlipidemia, tetrahydroberberrubine 9-O-(heptafluoro-4’-toluene)sulfonate was shown to reduce the cholesterol level by 23.5%, which is comparable with the eff ect of Simvastatin. At a concentration of 32 μg mL−1, tetrahydroberberrubine 9-O-pentafluorobenzenesulfonate inhibits the growth of the fungus Cryptococcus neoformans by 81.3±3.5%.

Original languageEnglish
Pages (from-to)1052-1060
Number of pages9
JournalRussian Chemical Bulletin
Volume68
Issue number5
DOIs
Publication statusPublished - 1 May 2019

Keywords

  • activity
  • antifungal
  • berberine
  • berberrubine
  • cholesterol
  • Cryptococcus neoformans
  • cytotoxicity
  • hyperlipidemia
  • sulfonate
  • BERBERINE
  • ANTIMICROBIAL ACTIVITY

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