Synthesis and structures of CuI,II complexes with a 2,2´-bipyridine derivative bearing a (+)-3-carene moiety

T. E. Kokina, L. A. Glinskaya, D. A. Piryazev, A. Yu Baranov, A. M. Agafontsev, Yu A. Eremina, E. V. Vorontsova, A. S. Bogomyakov, D. Yu Naumov, A. V. Tkachev, S. V. Larionov

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The complex salt {[CuL2][Cu4I6]•MeCN}n (1) and the compound [Cu4L3I4]•3 MeCN (2) (L is a chiral ligand bearing a natural monoterpene (+)-3-carene moiety) were synthesized. The crystal structures of compounds 1 and 2 were determined by X-ray diffraction. The structure of compound 1 consists of complex cations [CuL2]2+ (N3O2 polyhedron is a trigonal bipyramid) and CuI coordination polymers (CuI4 polyhedron is a tetrahedron) as anions. The experimental magnetic moment μeff at 300 K is 1.90 μB, which is consistent with the X-ray diffraction data and the assumption that compound 1 is mixed-valence. The structure of compound 2 comprises a tetranuclear CuI complex, in which three Cu atoms are coordinated by two N atoms of the ligand L and two I atoms, and the fourth Cu atom is coordinated by four I atoms (coordination polyhedra are distorted tetrahedra). Compounds L and 2 were found to influence the viability of human laryngeal carcinoma cells (Hep2). The IC50 value for complex 2 (13.0±1.7 μM) is substantially smaller than IC50 for compound L (30.5±0.5 μM).

Original languageEnglish
Pages (from-to)1251-1260
Number of pages10
JournalRussian Chemical Bulletin
Volume67
Issue number7
DOIs
Publication statusPublished - 1 Jul 2018

Keywords

  • chiral ligand
  • coordination framework
  • copper(I,II) complexes
  • crystal structure
  • cytotoxicity
  • iodide complex
  • terpenes
  • copper(I, II) complexes
  • COPPER-COMPLEXES
  • PHOTOLUMINESCENCE
  • CRYSTAL-STRUCTURE
  • PYRIDINE
  • ZINC(II)
  • COORDINATION-COMPOUNDS
  • PYRAZOLYLQUINOLINE
  • METAL-COMPLEXES

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