Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1)

A. L. Zakharenko; E. S. Mozhaitsev; E. V. Suslov; D. V. Korchagina; K. P. Volcho; N. F. Salakhutdinov; O. I. Lavrik

doi:10.1007/s10600-018-2443-7

Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1)

A. L. Zakharenko, E. S. Mozhaitsev, E. V. Suslov, D. V. Korchagina, K. P. Volcho, N. F. Salakhutdinov, O. I. Lavrik

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC₅₀ = 5.5–7.1 μM.

Original language	English
Pages (from-to)	672-676
Number of pages	5
Journal	Chemistry of Natural Compounds
Volume	54
Issue number	4
DOIs	https://doi.org/10.1007/s10600-018-2443-7
Publication status	Published - 1 Jul 2018

Keywords

adamantane
DNA repair inhibitor
monoterpene
Schiff base
tyrosyl-DNA phosphodiesterase 1
TARGET
CAMPTOTHECIN
BIOLOGICAL EVALUATION
TOP1
IDENTIFICATION
MOIETIES

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10.1007/s10600-018-2443-7

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Zakharenko, A. L., Mozhaitsev, E. S., Suslov, E. V., Korchagina, D. V., Volcho, K. P., Salakhutdinov, N. F., & Lavrik, O. I. (2018). Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1). Chemistry of Natural Compounds, 54(4), 672-676. https://doi.org/10.1007/s10600-018-2443-7

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abstract = "Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC50 = 5.5–7.1 μM.",

keywords = "adamantane, DNA repair inhibitor, monoterpene, Schiff base, tyrosyl-DNA phosphodiesterase 1, TARGET, CAMPTOTHECIN, BIOLOGICAL EVALUATION, TOP1, IDENTIFICATION, MOIETIES",

author = "Zakharenko, {A. L.} and Mozhaitsev, {E. S.} and Suslov, {E. V.} and Korchagina, {D. V.} and Volcho, {K. P.} and Salakhutdinov, {N. F.} and Lavrik, {O. I.}",

year = "2018",

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doi = "10.1007/s10600-018-2443-7",

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Zakharenko, AL, Mozhaitsev, ES, Suslov, EV, Korchagina, DV, Volcho, KP, Salakhutdinov, NF & Lavrik, OI 2018, 'Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1)', Chemistry of Natural Compounds, vol. 54, no. 4, pp. 672-676. https://doi.org/10.1007/s10600-018-2443-7

Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1). / Zakharenko, A. L.; Mozhaitsev, E. S.; Suslov, E. V.; Korchagina, D. V.; Volcho, K. P.; Salakhutdinov, N. F.; Lavrik, O. I.

In: Chemistry of Natural Compounds, Vol. 54, No. 4, 01.07.2018, p. 672-676.

Research output: Contribution to journal › Article › peer-review

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AU - Mozhaitsev, E. S.

AU - Suslov, E. V.

AU - Korchagina, D. V.

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AU - Salakhutdinov, N. F.

AU - Lavrik, O. I.

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KW - CAMPTOTHECIN

KW - BIOLOGICAL EVALUATION

KW - TOP1

KW - IDENTIFICATION

KW - MOIETIES

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