Synthesis and Inhibitory Properties of Imines Containing Monoterpenoid and Adamantane Fragments Against DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1 (Tdp1)

A. L. Zakharenko, E. S. Mozhaitsev, E. V. Suslov, D. V. Korchagina, K. P. Volcho, N. F. Salakhutdinov, O. I. Lavrik

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Six imines including four new ones were synthesized via the reaction of monoterpenoid aldehydes with aminoadamantanes. The inhibitory activities of the synthesized compounds against purified human recombinant DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (Tdp1) fell in the range IC50 = 5.5–7.1 μM.

Original languageEnglish
Pages (from-to)672-676
Number of pages5
JournalChemistry of Natural Compounds
Volume54
Issue number4
DOIs
Publication statusPublished - 1 Jul 2018

Keywords

  • adamantane
  • DNA repair inhibitor
  • monoterpene
  • Schiff base
  • tyrosyl-DNA phosphodiesterase 1
  • TARGET
  • CAMPTOTHECIN
  • BIOLOGICAL EVALUATION
  • TOP1
  • IDENTIFICATION
  • MOIETIES

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